ArticleMolecular pharmacology2018
Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M
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In one paragraph
Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the MEuropean journal of medicinal chemistry · 2023Article
- 30th Annual GPPharmaceuticals (Basel, Switzerland) · 2023Article
- Targeting the M1 muscarinic acetylcholine receptor in Alzheimer's disease.Neuronal signaling · 2022Review
- Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the MChemMedChem · 2021Article
- Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine DACS medicinal chemistry letters · 2020Article
- Current Advances in Allosteric Modulation of Muscarinic Receptors.Biomolecules · 2020Review
- Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias.Frontiers in pharmacology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Emma T van der WesthuizenDrug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.).
Arthur SpathisDrug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.).
Elham KhajehaliDrug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.).
Manuela JörgDrug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.).
Shailesh N MistryDrug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.).
Ben CapuanoDrug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.).
Andrew B TobinDrug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.).
Patrick M SextonDrug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.).
Peter J ScammellsDrug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.).
Celine ValantDrug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.).
Arthur ChristopoulosDrug Discovery Biology (E.T.W., A.S., E.K., P.M.S., C.V., A.C.) and Medicinal Chemistry (M.J., S.N.M., B.C., P.J.S.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (A.B.T.) Arthur.Christopoulos@monash.edu.
Monash University · AUDiscovery Institute · USUniversity of Glasgow · GB
Funding
Medical Research Council MC_UP_A600_1110Medical Research Council MR/P019366/1Wellcome Trust 201529Wellcome Trust 201529/Z/16/Z
Abstract
Positive allosteric modulators (PAMs) that target the M
Indexed as
AcetylcholineAllosteric RegulationAnimalsCHO CellsCholinergic AgonistsCricetulusHumansInositol PhosphatesPyridinesPyridonesQuinolonesReceptor, Muscarinic M1Signal TransductionThiadiazoles4-phenylpyridin-2-oneAcetylcholineCholinergic AgonistsInositol PhosphatesPyridinesPyridonesQuinolonesReceptor, Muscarinic M1Thiadiazolesxanomeline
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.