ArticleeLife2018
Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α
Open access · goldAbstract read
In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Exploring the protective effects of thalassemia against malaria in Africa: a systematic review.Systematic reviews · 2026Pooled it
- α-Thalassemia has no association with asymptomatic Plasmodium falciparum carriage in three ecological zones of Ghana.Scientific reports · 2026Article
- Article
- Article
- Blood group antigens and malaria susceptibility.Frontiers in cellular and infection microbiology · 2025Review
- Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype.PLoS pathogens · 2025Article
- ApoE: A new piece to the severe malaria puzzle.Pediatric research · 2024Article
- Dantu Blood Group Erythrocytes Form Large Plasmodium falciparum Rosettes Less Commonly.The American journal of tropical medicine and hygiene · 2024Article
- Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria.PLoS genetics · 2023Article
- The Defensive Interactions of Prominent Infectious Protozoan Parasites: The Host's Complement System.Biomolecules · 2022Review
- Genetics of cerebral malaria: pathogenesis, biomarkers and emerging therapeutic interventions.Cell & bioscience · 2022Review
- Association of TNF-Alpha, MBL2, NOS2, and G6PD with Malaria Outcomes in People in Southern Ghana.Genetics research · 2022Article
- Adaptive immunity selects against malaria infection blocking mutations.PLoS computational biology · 2020Article
- Human genetics and malaria resistance.Human genetics · 2020Review
- Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑αWellcome open research · 2020Article
- Rosetting revisited: a critical look at the evidence for host erythrocyte receptors inParasitology · 2020Review
- Evaluating the promise of inclusion of African ancestry populations in genomics.NPJ genomic medicine · 2020Review
- Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania.Nature communications · 2019Article
- Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects.BMC medical genomics · 2019Review
- Genetics of Malaria Inflammatory Responses: A Pathogenesis Perspective.Frontiers in immunology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 7 institutions in 6 countries.
D Herbert Opi *Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID http://orcid.org/0000-0002-4589-4365
Olivia Swann *Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.ORCID http://orcid.org/0000-0001-7386-2849
Alexander MachariaKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Sophie UyogaKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Gavin BandWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Carolyne M NdilaKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Ewen M HarrisonCentre for Medical Infomatics, Usher Insitute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.
Mahamadou A TheraMalaria Research and Training Centre, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali.ORCID http://orcid.org/0000-0002-2679-035X
Abdoulaye K KoneMalaria Research and Training Centre, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali.
Dapa A DialloMalaria Research and Training Centre, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali.
Ogobara K DoumboMalaria Research and Training Centre, Faculty of Medicine, Pharmacy, and Dentistry, University of Bamako, Bamako, Mali.
Kirsten E LykeDivision of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, United States.
Christopher V PloweDivision of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, United States.
Joann M MouldsLifeshare Blood Centers, Shreveport, United States.
Mohammed ShebbeKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Neema MturiKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Norbert PeshuKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Kathryn MaitlandKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Ahmed RazaCentre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Dominic P KwiatkowskiWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Kirk A RockettWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-6369-9299
Thomas N Williams *Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID http://orcid.org/0000-0003-4456-2382
J Alexandra Rowe *Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.ORCID http://orcid.org/0000-0002-7702-1892
Kenya Medical Research Institute · KEUniversity of Bamako · MLCentre for Human Genetics · GBCentre for Immunity, Infection and Evolution · GBUniversity of Maryland, Baltimore · USBurnet Institute · AUUniversity of Edinburgh · GB
Funding
Medical Research Council G19/9Medical Research Council MR/M006212/1Wellcome Trust 067431Wellcome Trust 084226Wellcome Trust 084538Wellcome Trust 091758Wellcome Trust 101910/Z/13/ZWellcome Trust 202800Wellcome Trust 202800/Z/16/ZWellcome Trust 203077Wellcome Trust 204911/Z/16/ZWellcome Trust 84538Wellcome Trust Senior Research Fellowship084226Wellcome Trust Senior Research Fellowship 091758Wellcome Trust Senior Research Fellowship202800
Abstract
Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (
Indexed as
Polymorphism, GeneticAdolescentalpha-ThalassemiaCase-Control StudiesChildChild, PreschoolFemaleGene FrequencyGenetic Association StudiesHumansInfantInfant, NewbornKenyaMalaria, CerebralMaleMaliCR1 protein, humanReceptors, Complement 3bAlpha thalassaemiaCerebral malariaComplement receptor 1epidemiologyglobal healthhumaninfectious disease<i>p. falciparum</i>Knops blood groupmicrobiology
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.