Evidence map›Paper›PMID 29690927›Full record

ArticleTrials2018

Effects of transcranial LED therapy on the cognitive rehabilitation for diffuse axonal injury due to severe acute traumatic brain injury: study protocol for a randomized controlled trial.

João Gustavo Rocha Peixoto Dos Santos, Ana Luiza Costa Zaninotto, Renato Amaro Zângaro, Ana Maria Costa Carneiro, Iuri Santana Neville, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira, Wellingson Silva Paiva

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03281759 (Effects of Transcranial LED Therapy on the Cognitive Rehabilitation for Diffuse Axonal Injury Due to Severe Acute Traumatic Brain Injury), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03281759 naunknown statusnot on this map

Effects of Transcranial LED Therapy on the Cognitive Rehabilitation for Diffuse Axonal Injury Due to Severe Acute Traumatic Brain Injury: Randomized Clinical Trial.

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2017 to 2018Enrolled30ConditionsDiffuse Axonal Brain Injury, Traumatic Brain InjuryArmsTranscranial LED Therapy (Active coil helmet), Transcranial LED Therapy (Inactive coil helmet)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  5. Inhibiting Mitochondrial CytochromeFrontiers in physiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

João Gustavo Rocha Peixoto Dos SantosDepartment of Neurological Surgery, University of São Paulo School of Medicine, 255 Dr. Enéas de Carvalho Aguiar Av., São Paulo, SP, 05403-010, Brazil. joao.gustavo.rps@gmail.com.
Ana Luiza Costa ZaninottoDivision of Neuropsychology, University of São Paulo General Hospital, São Paulo, Brazil.
Renato Amaro ZângaroCenter for Innovation, Technology and Education (CITÉ) SJ dos Campos, São Paulo, 12245-650, Brazil.
Ana Maria Costa CarneiroUniversity of São Paulo School of Nursing, São Paulo, Brazil.
Iuri Santana NevilleDepartment of Neurological Surgery, University of São Paulo School of Medicine, 255 Dr. Enéas de Carvalho Aguiar Av., São Paulo, SP, 05403-010, Brazil.
Almir Ferreira de AndradeDepartment of Neurological Surgery, University of São Paulo School of Medicine, 255 Dr. Enéas de Carvalho Aguiar Av., São Paulo, SP, 05403-010, Brazil.
Manoel Jacobsen TeixeiraDepartment of Neurological Surgery, University of São Paulo School of Medicine, 255 Dr. Enéas de Carvalho Aguiar Av., São Paulo, SP, 05403-010, Brazil.
Wellingson Silva PaivaDepartment of Neurological Surgery, University of São Paulo School of Medicine, 255 Dr. Enéas de Carvalho Aguiar Av., São Paulo, SP, 05403-010, Brazil.
Universidade de São Paulo · BRHospital São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhotobiomodulation describes the use of red or near-infrared light to stimulate or regenerate tissue. It was discovered that near-infrared wavelengths (800-900 nm) and red (600 nm) light-emitting diodes (LED) are able to penetrate through the scalp and skull and have the potential to improve the subnormal cellular activity of compromised brain tissue. Different experimental and clinical studies were performed to test LED therapy for traumatic brain injury (TBI) with promising results. One of the proposals of this present study is to develop different approaches to maximize the positive effects of this therapy and improve the quality of life of TBI patients. METHODS/

designThis is a double-blinded, randomized, controlled trial of patients with diffuse axonal injury (DAI) due to a severe TBI in an acute stage (less than 8 h). Thirty two patients will be randomized to active coil helmet and inactive coil (sham) groups in a 1:1 ratio. The protocol includes 18 sessions of transcranial LED stimulation (627 nm, 70 mW/cm DISCUSSION: This study evaluates early and delayed effects of TCLT on the cognitive rehabilitation for DAI following severe acute TBI. There is a paucity of studies regarding the use of this therapy for cognitive improvement in TBI. There are some experimental studies and case series presenting interesting results for TBI cognitive improvement but no clinical trials.

trial registrationClinicalTrials.gov, NCT03281759 . Registered on 13 September 2017.

Indexed as

AdolescentAdultBrainBrain Injuries, TraumaticBrazilCerebrovascular CirculationCognitionDiffuse Axonal InjuryDouble-Blind MethodFemaleGlasgow Coma ScaleHumansLasers, SemiconductorLow-Level Light TherapyMaleMiddle AgedBrain diseasesBrain injuriesCentral nervous system diseasesCraniocerebral traumaDiffuse axonal injuryLow-level light therapyNervous system diseasesNeurologic manifestationsQuality of lifeTrauma

Identifiers

PMID29690927
PMCPMC5916588
OpenAlexW2801247525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.