Evidence map›Paper›PMID 29690620›Full record

ArticleAntibiotics (Basel, Switzerland)2018

Silk Route to the Acceptance and Re-Implementation of Bacteriophage Therapy-Part II.

Expert round table on acceptance and re-implementation of bacteriophage therapy, Wilbert Sybesma, Christine Rohde, Pavol Bardy, Jean-Paul Pirnay, Ian Cooper, Jonathan Caplin, Nina Chanishvili, Aidan Coffey, Daniel De Vos and 7 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Phage therapeutics: from promises to practices and prospectives.Applied microbiology and biotechnology · 2021
    Review
  10. Review
  11. Article
  12. Engineered Bacteriophage Therapeutics: Rationale, Challenges and Future.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2021
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Bacteriophage Therapy: Developments and Directions.Antibiotics (Basel, Switzerland) · 2020
    Review
  18. Engineered bacteriophages as programmable biocontrol agents.Current opinion in biotechnology · 2020
    Review
  19. Phage Therapy in the Year 2035.Frontiers in microbiology · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 8 countries.

Expert round table on acceptance and re-implementation of bacteriophage therapy
Wilbert SybesmaDepartment of Neuro-Urology, Balgrist University Hospital, University of Zürich, CH-8008 Zürich, Switzerland. wilbert.sybesma@gmail.com.ORCID 0000-0002-3736-0558
Christine RohdeLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, D-38124 Braunschweig, Germany. chr@dsmz.de.
Pavol BardyDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno 611 37, Czech Republic. bardy.pavol@mail.muni.cz.ORCID 0000-0002-1223-2584
Jean-Paul PirnayLaboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, B-1120 Brussels, Belgium. jean-paul.pirnay@telenet.be.ORCID 0000-0002-6863-5219
Ian CooperSchool of Pharmacy and Biomolecular Sciences and School of Environment & Technology, University of Brighton, Brighton BN2 4GJ, UK. I.Cooper@brighton.ac.uk.ORCID 0000-0003-1955-5009
Jonathan CaplinSchool of Pharmacy and Biomolecular Sciences and School of Environment & Technology, University of Brighton, Brighton BN2 4GJ, UK. J.L.Caplin@brighton.ac.uk.
Nina ChanishviliEliava Institute of Bacteriophage, Microbiology and Virology, Tbilisi 0160, Georgia. nina.chanishvili@gmail.com.
Aidan CoffeyDepartment of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork T12 P928, UK. aidan.coffey@cit.ie.ORCID 0000-0003-4116-9913
Daniel De VosLaboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, B-1120 Brussels, Belgium. daniel_de_vos@skynet.be.
Amber Hartman ScholzLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, D-38124 Braunschweig, Germany. Amber.H.Scholz@dsmz.de.
Shawna McCallinDepartment of Fundamental Microbiology, University of Lausanne, CH-1015 Lausanne, Switzerland. shawna.mccallin@unil.ch.
Hilke Marie PüschnerLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, D-38124 Braunschweig, Germany. Hilke.Pueschner@dsmz.de.
Roman PantucekDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno 611 37, Czech Republic. pantucek@sci.muni.cz.ORCID 0000-0002-3950-675X
Rustam AminovSchool of Medicine & Dentistry, University of Aberdeen, Aberdeen AB25 2ZD, UK. rustam.aminov@gmail.com.
Jiří DoškařDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno 611 37, Czech Republic. doskar@sci.muni.cz.
D İpek KurtbӧkeGeneCology Research Centre and the Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore DC, QLD 4558, Australia. ikurtbok@usc.edu.au.ORCID 0000-0003-2056-2484
Masaryk University · CZLeibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures · DEQueen Astrid Military Hospital · BEUniversity of Aberdeen · GBUniversity of the Sunshine Coast · AUUniversity of Zurich · CHGeorge Eliava Institute of Bacteriophage, Microbiology and Virology · GEMunster Technological University · IEUniversity College Cork · IEUniversity of Brighton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This perspective paper follows up on earlier communications on bacteriophage therapy that we wrote as a multidisciplinary and intercontinental expert-panel when we first met at a bacteriophage conference hosted by the Eliava Institute in Tbilisi, Georgia in 2015. In the context of a society that is confronted with an ever-increasing number of antibiotic-resistant bacteria, we build on the previously made recommendations and specifically address how the Nagoya Protocol might impact the further development of bacteriophage therapy. By reviewing a number of recently conducted case studies with bacteriophages involving patients with bacterial infections that could no longer be successfully treated by regular antibiotic therapy, we again stress the urgency and significance of the development of international guidelines and frameworks that might facilitate the legal and effective application of bacteriophage therapy by physicians and the receiving patients. Additionally, we list and comment on several recently started and ongoing clinical studies, including highly desired double-blind placebo-controlled randomized clinical trials. We conclude with an outlook on how recently developed DNA editing technologies are expected to further control and enhance the efficient application of bacteriophages.

Indexed as

antibiotic resistancebacteriophagesbacteriophage therapyCRISPR CASNagoya Protocol

Identifiers

PMID29690620
PMCPMC6023077
OpenAlexW2800897238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.