Evidence map›Paper›PMID 29689411›Full record

ArticleBiomaterials2018

Radiolabeled polyoxometalate clusters: Kidney dysfunction evaluation and tumor diagnosis by positron emission tomography imaging.

Dalong Ni, Dawei Jiang, Hyung-Jun Im, Hector F Valdovinos, Bo Yu, Shreya Goel, Todd E Barnhart, Peng Huang, Weibo Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  13. Smart HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Review
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  16. Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dalong NiDepartment of Radiology, University of Wisconsin-Madison, Wisconsin, USA.
Dawei JiangDepartment of Radiology, University of Wisconsin-Madison, Wisconsin, USA; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, China.
Hyung-Jun ImDepartment of Radiology, University of Wisconsin-Madison, Wisconsin, USA; Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
Hector F ValdovinosDepartment of Radiology, University of Wisconsin-Madison, Wisconsin, USA; Department of Medical Physics, University of Wisconsin-Madison, Wisconsin, USA.
Bo YuDepartment of Radiology, University of Wisconsin-Madison, Wisconsin, USA.
Shreya GoelMaterials Science Program, University of Wisconsin-Madison, Wisconsin, USA.
Todd E BarnhartDepartment of Radiology, University of Wisconsin-Madison, Wisconsin, USA; Department of Medical Physics, University of Wisconsin-Madison, Wisconsin, USA.
Peng HuangDepartment of Radiology, University of Wisconsin-Madison, Wisconsin, USA; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University, Shenzhen, China.
Weibo CaiDepartment of Radiology, University of Wisconsin-Madison, Wisconsin, USA; Materials Science Program, University of Wisconsin-Madison, Wisconsin, USA; Department of Medical Physics, University of Wisconsin-Madison, Wisconsin, USA; University of Wisconsin Carbone Cancer Center, Wisconsin, USA. Electronic address: wcai@uwhealth.org.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Membranous Nanogenerators for in vivo Bio-mechanical Energy HarvestingR01EB021336 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, XUDONG · 2016 to 2020
$1.7M
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NIBIB NIH HHS R01 EB021336
6 · The paper itself

Abstract

Radiolabeled nanoprobes for positron emission tomography (PET) imaging has received special attention over the past decade, allowing for sensitive, non-invasive, and quantitative detection of different diseases. The rapidly renal clearable nanomaterials normally suffer from a low accumulation in the tumor through the enhanced permeability and retention (EPR) effect due to the rapidly reduced concentration in the blood circulation after renal clearance. It is highly important to design radiolabeled nanomaterials which can meet the balance between the rapid renal clearance and strong EPR effect within a suitable timescale. Herein, renal clearable polyoxometalate (POM) clusters of ultra-small size (∼1 nm in diameter) were readily radiolabeled with the oxophilic

Indexed as

Positron-Emission TomographyAnimalsCell Line, TumorKidneyKidney NeoplasmsMicePolyoxometalatesRadiopharmaceuticalsTungsten CompoundsUreteral ObstructionZirconiumpolyoxometalate IPolyoxometalatesRadiopharmaceuticalsTungsten CompoundsZirconiumEPR effectKidney dysfunctionNanomedicinePositron emission tomographyTumor diagnosis

Identifiers

PMID29689411
PMCPMC5962344

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.