ArticlePloS one2018
Inbreeding estimates in human populations: Applying new approaches to an admixed Brazilian isolate.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 30 citations in OpenAlex.
- Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations.Epigenetics · 2025Article
- Familial Searching utilising the National Forensic DNA Database of South Africa (NFDD-ZA) to aid in the identification of Missing Persons and Unidentified Human Remains.Forensic science international. Synergy · 2025Article
- A genomic tale of inbreeding in western Mediterranean human populations.Human genetics · 2025Article
- Visualization of Runs of Homozygosity and Classification Using Convolutional Neural Networks.Biology · 2025Article
- Pedigree Data from Six Rhesus Macaque (Journal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Population-based change-point detection for the identification of homozygosity islands.Bioinformatics (Oxford, England) · 2023Article
- A review of ancestrality and admixture in Latin America and the caribbean focusing on native American and African descendant populations.Frontiers in genetics · 2023Review
- Parent-offspring inference in inbred populations.Molecular ecology resources · 2022Article
- Review
- De novo assembly provides new insights into the evolution of Elaeagnus angustifolia L.Plant methods · 2022Article
- Whole-genome resequencing analysis of 20 Micro-pigs.Genes & genomics · 2020Article
- Origin and age of the causative mutations in KLC2, IMPA1, MED25 and WNT7A unravelled through Brazilian admixed populations.Scientific reports · 2018Article
- Understanding the Hidden Complexity of Latin American Population Isolates.American journal of human genetics · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The analysis of genomic data (~400,000 autosomal SNPs) enabled the reliable estimation of inbreeding levels in a sample of 541 individuals sampled from a highly admixed Brazilian population isolate (an African-derived quilombo in the State of São Paulo). To achieve this, different methods were applied to the joint information of two sets of markers (one complete and another excluding loci in patent linkage disequilibrium). This strategy allowed the detection and exclusion of markers that biased the estimation of the average population inbreeding coefficient (Wright's fixation index FIS), which value was eventually estimated as around 1% using any of the methods we applied. Quilombo demographic inferences were made by analyzing the structure of runs of homozygosity (ROH), which were adapted to cope with a highly admixed population with a complex foundation history. Our results suggest that the amount of ROH <2Mb of admixed populations should be somehow proportional to the genetic contribution from each parental population.
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