Evidence map›Paper›PMID 29688872›Full record

ArticleJournal of psychiatry & neuroscience : JPN2018

Neural correlates of emotional action control in anger-prone women with borderline personality disorder.

Katja Bertsch, Karin Roelofs, Paul Jonathan Roch, Bo Ma, Saskia Hensel, Sabine C Herpertz, Inge Volman

Abstract read
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In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Biofeedback and Treatment for Borderline Personality Disorder.Focus (American Psychiatric Publishing) · 2023
    Article
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Personality Disorders in Time of Pandemic.Current psychiatry reports · 2020
    Review
  18. Article
  19. Article
  20. Human Lateral Frontal Pole Contributes to Control over Emotional Approach-Avoidance Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katja BertschFrom the Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Bertsch, Herpertz); the Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (Roelofs); Division of Experimental Radiology, University of Heidelberg, Heidelberg, Germany (Ma); the Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Heidelberg, Germany (Hensel); and the Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK (Volman).
Karin RoelofsFrom the Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Bertsch, Herpertz); the Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (Roelofs); Division of Experimental Radiology, University of Heidelberg, Heidelberg, Germany (Ma); the Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Heidelberg, Germany (Hensel); and the Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK (Volman).
Paul Jonathan RochFrom the Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Bertsch, Herpertz); the Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (Roelofs); Division of Experimental Radiology, University of Heidelberg, Heidelberg, Germany (Ma); the Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Heidelberg, Germany (Hensel); and the Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK (Volman).
Bo MaFrom the Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Bertsch, Herpertz); the Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (Roelofs); Division of Experimental Radiology, University of Heidelberg, Heidelberg, Germany (Ma); the Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Heidelberg, Germany (Hensel); and the Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK (Volman).
Saskia HenselFrom the Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Bertsch, Herpertz); the Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (Roelofs); Division of Experimental Radiology, University of Heidelberg, Heidelberg, Germany (Ma); the Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Heidelberg, Germany (Hensel); and the Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK (Volman).
Sabine C HerpertzFrom the Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Bertsch, Herpertz); the Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (Roelofs); Division of Experimental Radiology, University of Heidelberg, Heidelberg, Germany (Ma); the Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Heidelberg, Germany (Hensel); and the Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK (Volman).
Inge VolmanFrom the Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany (Bertsch, Herpertz); the Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands (Roelofs); Division of Experimental Radiology, University of Heidelberg, Heidelberg, Germany (Ma); the Department of Psychosomatic Medicine, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Heidelberg, Germany (Hensel); and the Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK (Volman).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDifficulty in controlling emotional impulses is a crucial component of borderline personality disorder (BPD) that often leads to destructive, impulsive behaviours against others. In line with recent findings in aggressive individuals, deficits in prefrontal amygdala coupling during emotional action control may account for these symptoms.

methodsTo study the neurobiological correlates of altered emotional action control in individuals with BPD, we asked medication-free, anger-prone, female patients with BPD and age- and intelligence-matched healthy women to take part in an approach-avoidance task while lying in an MRI scanner. The task required controlling fast behavioural tendencies to approach happy and avoid angry faces. Additionally, before the task we collected saliva testosterone and self-reported information on tendencies to act out anger and correlated this with behavioural and functional MRI (fMRI) data.

resultsWe included 30 patients and 28 controls in our analysis. Patients with BPD reported increased tendencies to act out anger and were faster in approaching than avoiding angry faces than with healthy women, suggesting deficits in emotional action control in women with BPD. On a neural level, controlling fast emotional action tendencies was associated with enhanced activation in the antero- and dorsolateral prefrontal cortex across groups. Healthy women showed a negative coupling between the left dorsolateral prefrontal cortex and right amygdala, whereas this was absent in patients with BPD. LIMITATIONS: Specificity of results to BPD and sex differences remain unknown owing to the lack of clinical control groups and male participants.

conclusionThe results indicate reduced lateral prefrontal-amygdala communication during emotional action control in anger-prone women with BPD. The findings provide a possible neural mechanism underlying difficulties with controlling emotional impulses in patients with BPD.

Indexed as

AdolescentAdultAmygdalaAngerBorderline Personality DisorderCase-Control StudiesEmotionsFacial ExpressionFemaleHumansMagnetic Resonance ImagingMiddle AgedNeural PathwaysNeuroimagingPhotic StimulationPrefrontal CortexTestosterone

Identifiers

PMID29688872
PMCPMC5915237

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.