Evidence map›Paper›PMID 29688869›Full record

ArticlePediatric rheumatology online journal2018

Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis.

Merav Heshin-Bekenstein, Liat Perl, Aimee O Hersh, Emily von Scheven, Ed Yelin, Laura Trupin, Jinoos Yazdany, Erica F Lawson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric rheumatology online journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Merav Heshin-BekensteinDivision of Pediatric Rheumatology, University of California San Francisco, Benioff Children's Hospital, 550 16th Street, 5th Floor, San Francisco, CA, 94143-0632, USA. meravheshin@gmail.com.ORCID http://orcid.org/0000-0002-9488-6476
Liat PerlDivision of Pediatric Endocrinology, University of California San Francisco, San Francisco, CA, USA.
Aimee O HershDivision of Pediatric Rheumatology, University of Utah, Salt Lake City, UT, USA.
Emily von SchevenDivision of Pediatric Rheumatology, University of California San Francisco, Benioff Children's Hospital, 550 16th Street, 5th Floor, San Francisco, CA, 94143-0632, USA.
Ed YelinDivision of Rheumatology, University of California San Francisco, San Francisco, CA, USA.
Laura TrupinDivision of Rheumatology, University of California San Francisco, San Francisco, CA, USA.
Jinoos YazdanyDivision of Rheumatology, University of California San Francisco, San Francisco, CA, USA.
Erica F LawsonDivision of Pediatric Rheumatology, University of California San Francisco, Benioff Children's Hospital, 550 16th Street, 5th Floor, San Francisco, CA, 94143-0632, USA.
University of California, San Francisco · USLee University · USUniversity of Utah · US

Funding

The Interplay of Sociodemographic and Genetic Factors in SLE Health DisparitiesP60AR053308 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATZ, PATRICIA P · 2006 to 2016
$11.8M
RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2M
ACADEMIC RHEUMATOLOGY AND CLINICAL IMMUNOLOGYT32AR007304 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DAIKH, DAVID I · 1986 to 2018
$6.0M
NIAMS NIH HHS P30 AR070155NIAMS NIH HHS P60 AR-053308NIAMS NIH HHS P60 AR053308NIAMS NIH HHS T32-AR007304School of Medicine, University of California, San Francisco NCATS UCSF-CTSI UL1-TR001872
6 · The paper itself

Abstract

backgroundTo compare final height to mid-parental target height among adults with childhood-onset systemic lupus erythematosus (cSLE) versus adult-onset SLE (aSLE), and to evaluate the impact of age at SLE onset on final height.

methodsData derived from the Lupus Outcomes Study, a longitudinal cohort of adults with SLE, was used for this cross-sectional analysis (N = 728). Participants aged 18-63 years with complete height data were included (N = 566) and were classified as cSLE if age at diagnosis was < 18 years (N = 72). The Tanner formula was used to calculate mid-parental target height. Multivariate linear regression was used to determine mean difference between final height and target height. Multivariate logistic regression was used to compare odds of substantially reduced final height, defined as > 2 SD below target height. Separate analyses were conducted for females and males to account for differences in timing of the pubertal growth spurt for each sex.

resultsParticipants with cSLE were, on average, 2.4 cm shorter than their target height (95% CI -4, - 0.7). The adjusted odds ratio (OR) for substantially reduced final height was 3.9 (95% CI + 2.0, + 7.2, p < 0.001) as compared to participants with aSLE. Females diagnosed between 11 and 13 years were at greatest risk for substantially reduced final height, with adjusted OR of 11.2 (95% CI + 3.4, + 36.3) as compared to participants with aSLE (p < 0.001).

conclusionscSLE is associated with shorter-than-expected final height. Onset of SLE in the pubertal period, near the time of maximum linear growth, may have a particularly significant impact on final height.

Indexed as

Body HeightAdolescentAdultAge FactorsAge of OnsetChildCross-Sectional StudiesFemaleHumansLongitudinal StudiesLupus Erythematosus, SystemicMaleMiddle AgedRisk FactorsYoung AdultAdult-onset SLEChildhood-onset SLEFinal adult heightGrowth hormoneMid-parental target heightSLE

Identifiers

PMID29688869
PMCPMC5913867
OpenAlexW2806238211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.