Evidence map›Paper›PMID 29688697›Full record

ArticleACS applied materials & interfaces2018

Dual Suppression Effect of Magnetic Induction Heating and Microencapsulation on Ice Crystallization Enables Low-Cryoprotectant Vitrification of Stem Cell-Alginate Hydrogel Constructs.

Xiaoli Liu, Gang Zhao, Zhongrong Chen, Fazil Panhwar, Xiaoming He

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 85 citations in OpenAlex.

  1. Review
  2. Microfluidic Platforms for Cryopreservation.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Advanced Rewarming Technologies for Cryopreservation.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Chemical approaches to cryopreservation.Nature reviews. Chemistry · 2022
    Review
  16. Article
  17. Vitrification and Nanowarming of Kidneys.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  18. Article
  19. Article
  20. Ice Inhibition for Cryopreservation: Materials, Strategies, and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Xiaoli LiuDepartment of Electronic Science and Technology , University of Science and Technology of China , Hefei 230027 , Anhui , China.
Gang ZhaoDepartment of Electronic Science and Technology , University of Science and Technology of China , Hefei 230027 , Anhui , China.ORCID http://orcid.org/0000-0002-0201-1825
Zhongrong ChenDepartment of Electronic Science and Technology , University of Science and Technology of China , Hefei 230027 , Anhui , China.
Fazil PanhwarDepartment of Electronic Science and Technology , University of Science and Technology of China , Hefei 230027 , Anhui , China.
Xiaoming HeFischell Department of Bioengineering , University of Maryland , College Park , Maryland 20742 , United States.ORCID http://orcid.org/0000-0003-0125-6086
University of Science and Technology of China · CNUniversity of Maryland, College Park · US

Funding

Microfluidic encapsulation of ovarian follicles for biomimetic 3D culture andcryopreservationR01EB023632 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI HE, XIAOMING · 2017 to 2020
$1.6M
Microencapsulation of oocytes for low-CPA (cryoprotectant) vitrificationR01EB012108 · NIBIB · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HE, XIAOMING · 2011 to 2014
$1.3M
NIBIB NIH HHS R01 EB012108NIBIB NIH HHS R01 EB023632
6 · The paper itself

Abstract

Stem cells microencapsulated in hydrogel as stem cell-hydrogel constructs have wide applications in the burgeoning cell-based medicine. Due to their short shelf life at ambient temperature, long-term storage or banking of the constructs is essential to the "off-the-shelf" ready availability needed for their widespread applications. As a high-efficiency, easy-to-operate, low-toxicity, and low-cost method for long-term storage of the constructs, low-cryoprotectant (CPA) vitrification has attracted tremendous attention recently. However, we found many cells in the stem cell-alginate constructs (∼500 μm in diameter) could not attach to the substrate post low-CPA vitrification with ∼2 M penetrating CPAs. To address this problem, we introduced nanowarming via magnetic induction heating (MIH) of Fe

Indexed as

Stem CellsAlginic AcidCell SurvivalCryopreservationCryoprotective AgentsCrystallizationDrug CompoundingHot TemperatureHydrogelsIceVitrificationAlginic AcidCryoprotective AgentsHydrogelsIceFe3O4 nanoparticlesmagnetic induction heatingnanowarmingstem cell−hydrogel constructsvitrification

Identifiers

PMID29688697
PMCPMC6054798
OpenAlexW2801403250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.