ArticleMolecular biology and evolution2018
Natural Selection and Origin of a Melanistic Allele in North American Gray Wolves.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- A legacy of genetic entanglement with wolves shapes modern dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The impacts of European arrival on Australian dingoes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mating system of free-ranging domestic dogs and its consequences for dog evolution.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Whole-Genome Data to Investigate Recent and Historical Dog Introgression Patterns in Italian Wolves.Ecology and evolution · 2025Article
- Potential Adaptive Introgression From Dogs in Iberian Grey Wolves (Canis lupus).Molecular ecology · 2025Article
- Ancient dog introgression into the Iberian wolf genome may have facilitated adaptation to human-dominated landscapes.Genome research · 2025Article
- Color polymorphic carnivores have faster speciation rates.Scientific reports · 2024Article
- The natural history and ecology of melanism in red wolf and coyote populations of the southeastern United States - evidence for Gloger's rule.BMC zoology · 2022Article
- Human-modified canids in human-modified landscapes: The evolutionary consequences of hybridization for grey wolves and free-ranging domestic dogs.Evolutionary applications · 2021Article
- K Locus Effects in Gray Wolves: Experimental Assessment of TLR3 Signaling and the Gene Expression Response to Canine Distemper Virus.The Journal of heredity · 2021Article
- Article
- Correlational selection in the age of genomics.Nature ecology & evolution · 2021Review
- Article
- Whole-genome analyses provide no evidence for dog introgression in Fennoscandian wolf populations.Evolutionary applications · 2021Article
- Patterns and processes of pathogen exposure in gray wolves across North America.Scientific reports · 2021Article
- Wolf Delisting Challenges Demonstrate Need for an Improved Framework for Conserving Intraspecific Variation under the Endangered Species Act.Bioscience · 2021Article
- Host-parasite co-evolution and its genomic signature.Nature reviews. Genetics · 2020Review
- Population Genomics Training for the Next Generation of Conservation Geneticists: ConGen 2018 Workshop.The Journal of heredity · 2020Article
- BetaScan2: Standardized Statistics to Detect Balancing Selection Utilizing Substitution Data.Genome biology and evolution · 2020Article
- Global Phylogeographic and Admixture Patterns in Grey Wolves and Genetic Legacy of An Ancient Siberian Lineage.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 4 countries.
Funding
Abstract
Pigmentation is often used to understand how natural selection affects genetic variation in wild populations since it can have a simple genetic basis, and can affect a variety of fitness-related traits (e.g., camouflage, thermoregulation, and sexual display). In gray wolves, the K locus, a β-defensin gene, causes black coat color via a dominantly inherited KB allele. The allele is derived from dog-wolf hybridization and is at high frequency in North American wolf populations. We designed a DNA capture array to probe the geographic origin, age, and number of introgression events of the KB allele in a panel of 331 wolves and 20 dogs. We found low diversity in KB, but not ancestral ky, wolf haplotypes consistent with a selective sweep of the black haplotype across North America. Further, North American wolf KB haplotypes are monophyletic, suggesting that a single adaptive introgression from dogs to wolves most likely occurred in the Northwest Territories or Yukon. We use a new analytical approach to date the origin of the KB allele in Yukon wolves to between 1,598 and 7,248 years ago, suggesting that introgression with early Native American dogs was the source. Using population genetic simulations, we show that the K locus is undergoing natural selection in four wolf populations. We find evidence for balancing selection, specifically in Yellowstone wolves, which could be a result of selection for enhanced immunity in response to distemper. With these data, we demonstrate how the spread of an adaptive variant may have occurred across a species' geographic range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.