ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Frailty Is Inversely Related to Age at Menopause and Elevated in Women Who Have Had a Hysterectomy: An Analysis of the Canadian Longitudinal Study on Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Gender differences for frailty in HIV-infected patients on stable antiretroviral therapy and with an undetectable viral load.PloS one · 2019Trial
- Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- What Do We Know About Prevention of Frailty in Women?American journal of lifestyle medicine · 2025Review
- Prevalence of frailty and associated factors in Shanghai older community-dwelling adults: a cross-sectional study.BMJ open · 2025Article
- Menopausal status, transition, and age at menopause with accelerated biological aging across multiple organ systems: findings from two cohort studies.BMC medicine · 2025Article
- Applying a life course approach to elucidate the biology of sex differences in frailty: early-life gonadectomy diminishes late-life robustness in male and female dogs in the Exceptional Aging in Rottweilers Study.Biology of sex differences · 2025Article
- Associations between dietary inflammatory index with menopause and hysterectomy: findings from a national health and nutrition examination survey.BMC public health · 2025Article
- Unilateral Oophorectomy and Age at Natural Menopause: A Longitudinal Community-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Multiomic profiling reveals timing of menopause predicts prefrontal cortex aging and cognitive function.Aging cell · 2025Article
- Article
- Reproductive factors and risk of physical frailty among Chinese women living in Singapore.The journal of nutrition, health & aging · 2024Article
- Age- and sex-specific associations of frailty with mortality and healthcare utilization in community-dwelling adults from ontario, Canada.BMC geriatrics · 2024Article
- Comparison of three frailty measures for predicting hospitalization and mortality in the Canadian Longitudinal Study on Aging.Aging clinical and experimental research · 2024Article
- Extended-release metformin improves cognitive impairment in frail older women with hypertension and diabetes: preliminary results from the LEOPARDESS Study.Cardiovascular diabetology · 2023Article
- Development and validation of a physical frailty phenotype index-based model to estimate the frailty index.Diagnostic and prognostic research · 2023Article
- Adverse childhood experiences are associated with increased risk of hysterectomy and bilateral oophorectomy: A national retrospective cohort study of women in England.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- Article
- Sex Differences in the Relation Between Frailty and Endothelial Dysfunction in Old Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- NK- and T-cell granzyme B and K expression correlates with age, CMV infection and influenza vaccine-induced antibody titres in older adults.Frontiers in aging · 2022Article
- What We Know about the Long-Term Risks of Hysterectomy for Benign Indication-A Systematic Review.Journal of clinical medicine · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFrailty is a complex pathophysiological phenomenon that will impact a significant proportion of adults over the age of 65 and contributes to the risk of several adverse health outcomes. Although women have a disproportionately higher risk of frailty, the sex-specific factors related to this syndrome are not well described. Hence, we sought to examine the relationship of age at menopause, hysterectomy status, and hormone replacement therapy use with prevalent frailty in older women.
methodsWe performed a cross-sectional analysis of the Canadian Longitudinal Study on Aging (CLSA) Baseline Comprehensive Cohort (n = 30,097, 45-85 years old). Frailty was operationalized using both the deficit accumulation (frailty index) and frailty phenotype (Fried) models. Postmenopausal women were categorized as follows: premature (30-39 years), early (40-45 years), normal (46-54 years), and late (55+ years) menopause, or hysterectomy. Associations were determined using multivariate analysis, adjusting for sociodemographics, lifestyle factors, social support, and hormone replacement therapy use.
resultsAge at menopause was inversely related to frailty in older Canadian women. The frailty index decreased 1.2% of the mean (p < .001) with every year of menopause onset and was significantly higher for women in the premature (24%; p < .001) and early (7%; p < .01) menopause and hysterectomy (21%; p < .001) groups, compared to the normal menopause group. The odds for being classified as frail using Fried's criteria was higher for the premature menopause (OR = 1.33, 95% CI = 0.72-2.27) and hysterectomy (OR = 1.59, 95% CI = 1.25-2.02) groups.
conclusionsOur study supports a role for age at menopause and hysterectomy in the risk of frailty in older women and warrants further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.