ArticleCerebral cortex (New York, N.Y. : 1991)2019
Gestational Age is Dimensionally Associated with Structural Brain Network Abnormalities Across Development.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Motor skills and working memory capacity in preadolescents born very preterm.Developmental medicine and child neurology · 2026Article
- The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology.Communications biology · 2026Article
- Article
- The uniqueness of human vulnerability to brain aging in great ape evolution.Science advances · 2024Article
- Early life factors and structural brain network in children with overweight/obesity: The ActiveBrains project.Pediatric research · 2024Article
- Development of white matter fiber covariance networks supports executive function in youth.Cell reports · 2023Article
- Development of White Matter Fiber Covariance Networks Supports Executive Function in Youth.bioRxiv : the preprint server for biology · 2023Article
- Lower gestational age is associated with lower cortical volume and cognitive and educational performance in adolescence.BMC medicine · 2022Article
- Inter- and intra-individual variation in brain structural-cognition relationships in aging.NeuroImage · 2022Article
- Radiomics of Contrast-Enhanced Computed Tomography: A Potential Biomarker for Pretreatment Prediction of the Response toFrontiers in cell and developmental biology · 2022Article
- The mediating role of executive function in the relationship between self-stigma and self-injury or suicidal ideation among men who have sex with men living with HIV.Frontiers in public health · 2022Article
- Functional Connectivity Network Disruption Underlies Domain-Specific Impairments in Attention for Children Born Very Preterm.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Diagnostic Value of Diffusion Tensor Imaging for Infants' Brain Development Retardation Caused by Pre-Eclampsia.Contrast media & molecular imaging · 2021Article
- Altered orbitofrontal activation in preterm-born young adolescents during performance of a reality filtering task.NeuroImage. Clinical · 2021Article
- Approaches to Defining Common and Dissociable Neurobiological Deficits Associated With Psychopathology in Youth.Biological psychiatry · 2020Review
- Maternal Dietary Intake of Omega-3 Fatty Acids Correlates Positively with Regional Brain Volumes in 1-Month-Old Term Infants.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Neurostructural Heterogeneity in Youths With Internalizing Symptoms.Biological psychiatry · 2020Article
- Early-life adversity and neurological disease: age-old questions and novel answers.Nature reviews. Neurology · 2019Review
- Linked dimensions of psychopathology and connectivity in functional brain networks.Nature communications · 2018Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
Abstract
Prematurity is associated with diverse developmental abnormalities, yet few studies relate cognitive and neurostructural deficits to a dimensional measure of prematurity. Leveraging a large sample of children, adolescents, and young adults (age 8-22 years) studied as part of the Philadelphia Neurodevelopmental Cohort, we examined how variation in gestational age impacted cognition and brain structure later in development. Participants included 72 preterm youth born before 37 weeks' gestation and 206 youth who were born at term (37 weeks or later). Using a previously-validated factor analysis, cognitive performance was assessed in three domains: (1) executive function and complex reasoning, (2) social cognition, and (3) episodic memory. All participants completed T1-weighted neuroimaging at 3 T to measure brain volume. Structural covariance networks were delineated using non-negative matrix factorization, an advanced multivariate analysis technique. Lower gestational age was associated with both deficits in executive function and reduced volume within 11 of 26 structural covariance networks, which included orbitofrontal, temporal, and parietal cortices as well as subcortical regions including the hippocampus. Notably, the relationship between lower gestational age and executive dysfunction was accounted for in part by structural network deficits. Together, these findings emphasize the durable impact of prematurity on cognition and brain structure, which persists across development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.