Evidence map›Paper›PMID 29688276›Full record

Trial reportCerebral cortex (New York, N.Y. : 1991)2018

Frontal Transcranial Direct Current Stimulation Induces Dopamine Release in the Ventral Striatum in Human.

Clara Fonteneau, Jérome Redoute, Frédéric Haesebaert, Didier Le Bars, Nicolas Costes, Marie-Françoise Suaud-Chagny, Jérome Brunelin

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 97 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01876524 nacompletednot on this map

Transcranial Random Noise Stimulation in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology Patients

TypeinterventionalSponsorSpanish Foundation for Neurometrics DevelopmentRan2013 to 2014Enrolled225ConditionsSubstance Use Disorder, Attention Deficit Disorder With Hyperactivity, Bipolar Disorder, SchizophreniaArmsTranscranial Random Noise Stimulation
NCT04815122 unknown statusnot on this mapstarted 2021, after this paper: background citation

Correlation Between the Presence of COMT Val158Met Polymorphism and Dopaminergic Transporter Density (DAT) in Obese Young Women

TypeobservationalSponsorUniversity of Sao PauloRan2021 to 2021Enrolled38ConditionsObesityArmsSPECT TRODAT-1
NCT04964427 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effects of Methylphenidate (MPH) and Non-invasive Brain Stimulation (tDCS) on Inhibitory Control Children With Attention-Deficit/Hyperactivity Disorder (ADHD)

TypeinterventionalSponsorBambino Gesù Hospital and Research InstituteRan2021 to 2022Enrolled26ConditionsAttention Deficit Hyperactivity DisorderArmsMethylphenidate, anodal tDCS, sham tDCS
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Clara FonteneauINSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response Team, Lyon, France.
Jérome RedouteCentre d'Etude et de Recherche Multimodal et Pluridisciplinaire en Imagerie du Vivant (CERMEP-Imagerie du vivant), Lyon, Lyon, Auvergne-Rhône-Alpes, France.
Frédéric HaesebaertINSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response Team, Lyon, France.
Didier Le BarsCentre d'Etude et de Recherche Multimodal et Pluridisciplinaire en Imagerie du Vivant (CERMEP-Imagerie du vivant), Lyon, Lyon, Auvergne-Rhône-Alpes, France.
Nicolas CostesCentre d'Etude et de Recherche Multimodal et Pluridisciplinaire en Imagerie du Vivant (CERMEP-Imagerie du vivant), Lyon, Lyon, Auvergne-Rhône-Alpes, France.
Marie-Françoise Suaud-ChagnyINSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response Team, Lyon, France.
Jérome BrunelinINSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response Team, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A single transcranial direct current stimulation (tDCS) session applied over the dorsolateral prefrontal cortex (DLFPC) can be associated with procognitive effects. Furthermore, repeated DLPFC tDCS sessions are under investigation as a new therapeutic tool for a range of neuropsychiatric conditions. A possible mechanism explaining such beneficial effects is a modulation of meso-cortico-limbic dopamine transmission. We explored the spatial and temporal neurobiological effects of bifrontal tDCS on subcortical dopamine transmission during and immediately after the stimulation. In a double blind sham-controlled study, 32 healthy subjects randomly received a single session of either active (20 min, 2 mA; n = 14) or sham (n = 18) tDCS during a dynamic positron emission tomography scan using [11C]raclopride binding. During the stimulation period, no significant effect of tDCS was observed. After the stimulation period, compared with sham tDCS, active tDCS induced a significant decrease in [11C]raclopride binding potential ratio in the striatum, suggesting an increase in extracellular dopamine in a part of the striatum involved in the reward-motivation network. The present study provides the first evidence that bifrontal tDCS induces neurotransmitter release in polysynaptic connected subcortical areas. Therefore, levels of dopamine activity and reactivity should be a new element to consider for a general hypothesis of brain modulation by bifrontal tDCS.

Indexed as

AdultAnalysis of VarianceDopamineDopamine AntagonistsDouble-Blind MethodFemaleFunctional LateralityHumansMagnetic Resonance ImagingMalePositron-Emission TomographyPrefrontal CortexRacloprideTime FactorsTranscranial Direct Current StimulationVentral StriatumDopamineDopamine AntagonistsRaclopride

Identifiers

PMID29688276
PMCPMC5998959

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.