ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
A Longitudinal Study of Trunk Muscle Properties and Severity of Thoracic Kyphosis in Women and Men: The Framingham Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The trial behind it
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Secondary analysis of change in physical function after exercise intervention in older adults with hyperkyphosis and low physical function.BMC geriatrics · 2021Trial
- Association Between Computed-Tomography-Derived Erector Spinae Muscle Characteristics and Swallowing Outcomes in Older Patients with Pneumonia.Healthcare (Basel, Switzerland) · 2026Article
- Reliability and Validity of Isometric Back Extensor Strength Measurements Using Hand-Held and Isokinetic Dynamometry in Sitting and Semi-Standing Positions.Spine surgery and related research · 2026Article
- Sex-specific patterns of skeletal muscle aging at the L3 level: a quantitative study based on opportunistic CT.BMC musculoskeletal disorders · 2026Article
- Gluteal Muscle Degeneration Is Associated with Compensation Failure in Age-Related Spinopelvic Malalignment: A Cross-Sectional Study.Spine surgery and related research · 2026Article
- Association of muscle mass and quality with functional decline in older patients with pneumonia: single-center retrospective observational study in Japan.BMC pulmonary medicine · 2026Observational
- Characterizing aging-related genetic and physiological determinants of spinal curvature.Communications medicine · 2025Article
- Gait Disturbance in Patients with Schizophrenia in Relation to Walking Speed, Ankle Joint Range of Motion, Body Composition, and Extrapyramidal Symptoms.Healthcare (Basel, Switzerland) · 2025Article
- Intermuscular adipose tissue affected muscle density more than intramuscular adipose tissue content with opportunistic screening at abdominal CT.Scientific reports · 2025Article
- Association of vertebral fractures with worsening degenerative changes of the spine: a longitudinal study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Holistic Approaches in Endometriosis - as an Effective Method of Supporting Traditional Treatment: A Systematic Search and Narrative Review.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Relationship among Osteoporosis, Sarcopenia, Locomotive Syndrome, and Spinal Kyphosis in Older Individuals Living in a Local Mountain Area.Asian spine journal · 2023Article
- Glycerol induced paraspinal muscle degeneration leads to hyper-kyphotic spinal deformity in wild-type mice.Scientific reports · 2023Article
- Association between characteristics of swallowing-related muscles and trunk muscle mass.Scientific reports · 2023Observational
- Reliability of the Smartphone Application Inclinometer and Flexicurve in Measuring Thoracic Kyphosis.Cureus · 2023Article
- Computed tomography-based paravertebral muscle density predicts subsequent vertebral fracture risks independently of bone mineral density in postmenopausal women following percutaneous vertebral augmentation.Aging clinical and experimental research · 2022Article
- Probabilistic prediction of segmental body composition in Iranian children and adolescents.BMC pediatrics · 2022Article
- Changes in cross-sectional areas of posterior extensor muscles in thoracic spine: a 10-year longitudinal MRI study.Scientific reports · 2022Article
- Metabolic changes in aging humans: current evidence and therapeutic strategies.The Journal of clinical investigation · 2022Review
- Myosteatosis Significantly Predicts Persistent Dyspnea and Mobility Problems in COVID-19 Survivors.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundCross-sectional studies suggest that trunk muscle morphology in the lumbar spine is an important determinant of kyphosis severity in older adults. The contribution of age-related changes in muscle morphology in the thoracic and lumbar spine to progression of kyphosis is not known. Our objective was to determine cross-sectional and longitudinal associations of thoracic and lumbar muscle size and density with kyphosis.
methodsParticipants were 1,087 women and men (mean age: 61 years) of the Framingham Heart Study who underwent baseline and follow-up quantitative computed tomography (QCT) scanning 6 years apart. We used QCT scans to measure trunk muscle cross-sectional area (CSA, cm2) and density (HU) at the thoracic and lumbar spine and Cobb angle (degrees) from T4 to T12. Linear regression models estimated the association between muscle morphology and kyphosis.
resultsAt baseline, smaller muscle CSA and lower density of thoracic (but not lumbar) spine muscles were associated with a larger (worse) Cobb angle in women and men. For example, each standard deviation decrease in baseline thoracic paraspinal muscle CSA was associated with a larger baseline Cobb angle in women (3.7 degrees, 95% CI: 2.9, 4.5) and men (2.5 degrees, 95% CI: 1.6, 3.3). Longitudinal analyses showed that loss of muscle CSA and density at the thoracic and lumbar spine was not associated with progression of kyphosis.
conclusionsOur findings suggest that kyphosis severity is related to smaller and lower density trunk muscles at the thoracic spine. Future studies are needed to determine how strengthening mid-back musculature alters muscle properties and contributes to preventing kyphosis progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.