ArticleEnvironmental health perspectives2018
Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study).
Article in Environmental health perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 200 citations in OpenAlex.
- Light at night exposure and risk of breast cancer: a meta-analysis of observational studies.Frontiers in public health · 2023Pooled it
- Light at night and risk of breast cancer: a systematic review and dose-response meta-analysis.International journal of health geographics · 2021Pooled it
- Prolonged exposure to artificial light and carcinogenesis: A systematic review of oncostatic mechanisms associated with melatonin pathways.Photochemistry and photobiologyPooled it
- Circadian clock control of breast cancer hallmarks: molecular mechanisms and therapeutic implications.Cancer metastasis reviews · 2026Review
- Circadian rhythm and the molecular clock in endothelial function of the cardiovascular system.Molecular and cellular biochemistry · 2026Review
- Circadian rhythm-related miR-6883-5p suppresses enzalutamide-resistant prostate cancer.Non-coding RNA research · 2026Article
- Light pollution: environmental and health impacts at high latitudes.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Review
- Article
- Only shine the light where and when it is needed - the impact of light pollution.Future healthcare journal · 2025Article
- Synergistic effects of outdoor nighttime light, air pollution, and PMBMC public health · 2025Article
- Associations of light at night exposure and environmental pollutants with risk for thyroid cancer in Fujian, China: a spatio-temporal analysis.BMC public health · 2025Article
- Digital dawn or dimming dusk? the dual impact of light pollution and digital economic expansion on senior cognitive function health in China.BMC public health · 2025Article
- Investigating the role of neighborhood socioeconomic status and germline genetics on prostate cancer risk.HGG advances · 2025Article
- Role of the period family in mediating the interplay between circadian disruption and cancer (Review).Oncology letters · 2025Review
- Outdoor Exposure to Artificial Light at Night and Breast Cancer Risk: A Case-Control Study Nested in the E3N-Generations Cohort.Environmental health perspectives · 2025Article
- Outdoor artificial light-at-night and cardiometabolic disease risk: an urban perspective from the Catalan GCAT cohort study.American journal of epidemiology · 2025Article
- Night shift work and prostate cancer: a large cohort study from UK Biobank and Mendelian randomisation study.BMJ open · 2024Article
- Night shift-induced circadian disruption: links to initiation of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and risk of hepatic cancer.Hepatoma research · 2024Article
- Exposure to Light at Night and Risk of Cancer: A Systematic Review, Meta-Analysis, and Data Synthesis.Cancers · 2024Review
- Postnatal nighttime light exposure and infant temperament at age 12 months: mediating role of genus Akkermansia.European child & adolescent psychiatry · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 14 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNight shift work, exposure to light at night (ALAN) and circadian disruption may increase the risk of hormone-dependent cancers.
objectivesWe evaluated the association of exposure to ALAN during sleeping time with breast and prostate cancer in a population based multicase-control study (MCC-Spain), among subjects who had never worked at night. We evaluated chronotype, a characteristic that may relate to adaptation to light at night.
methodsWe enrolled 1,219 breast cancer cases, 1,385 female controls, 623 prostate cancer cases, and 879 male controls from 11 Spanish regions in 2008-2013. Indoor ALAN information was obtained through questionnaires. Outdoor ALAN was analyzed using images from the International Space Station (ISS) available for Barcelona and Madrid for 2012-2013, including data of remotely sensed upward light intensity and blue light spectrum information for each geocoded longest residence of each MCC-Spain subject.
resultsAmong Barcelona and Madrid participants with information on both indoor and outdoor ALAN, exposure to outdoor ALAN in the blue light spectrum was associated with breast cancer [adjusted odds ratio (OR) for highest vs. lowest tertile, OR=1.47; 95% CI: 1.00, 2.17] and prostate cancer (OR=2.05; 95% CI: 1.38, 3.03). In contrast, those exposed to the highest versus lowest intensity of outdoor ALAN were more likely to be controls than cases, particularly for prostate cancer. Compared with those who reported sleeping in total darkness, men who slept in "quite illuminated" bedrooms had a higher risk of prostate cancer (OR=2.79; 95% CI: 1.55, 5.04), whereas women had a slightly lower risk of breast cancer (OR=0.77; 95% CI: 0.39, 1.51).
conclusionBoth prostate and breast cancer were associated with high estimated exposure to outdoor ALAN in the blue-enriched light spectrum. https://doi.org/10.1289/EHP1837.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.