ArticleMagnetic resonance in medicine2018
Quantitative susceptibility mapping of articular cartilage: Ex vivo findings at multiple orientations and following different degradation treatments.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Simultaneous 3-D Adiabatic TNMR in biomedicine · 2026Article
- Addressing fatty tissue in quantitative susceptibility mapping of human knee cartilage.Magma (New York, N.Y.) · 2025Article
- Quantitative susceptibility mapping of the human carotid artery: Assessing sensitivity to elastin and collagen ex vivo.Magnetic resonance in medicine · 2025Article
- Quantitative MRI methods for the assessment of structure, composition, and function of musculoskeletal tissues in basic research and preclinical applications.Magma (New York, N.Y.) · 2024Review
- Quantitative susceptibility and T1Osteoarthritis and cartilage open · 2024Article
- Epiphyseal cartilage vascular architecture at the distal humeral osteochondritis dissecans predilection site in juvenile pigs.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- QSM Throughout the Body.Journal of magnetic resonance imaging : JMRI · 2023Review
- Quantitative Susceptibility Mapping versus R2*-based Histogram Analysis for Evaluating Liver Fibrosis: Preliminary Results.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Relaxation anisotropy of quantitative MRI parameters in biological tissues.Scientific reports · 2022Article
- Simultaneous Quantitative Susceptibility Mapping of Articular Cartilage and Cortical Bone of Human Knee Joint Using Ultrashort Echo Time Sequences.Frontiers in endocrinology · 2022Article
- Effects of Angular Resolution andCartilage · 2021Article
- Diffusion tensor imaging and arterial tissue: establishing the influence of arterial tissue microstructure on fractional anisotropy, mean diffusivity and tractography.Scientific reports · 2020Article
- Evaluation of the Suitability of Miniature Pigs as an Animal Model of Juvenile Osteochondritis Dissecans.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Quantitative susceptibility mapping of articular cartilage in patients with osteoarthritis at 3T.Journal of magnetic resonance imaging : JMRI · 2019Article
- Quantitative susceptibility mapping of articular cartilage: Ex vivo findings at multiple orientations and following different degradation treatments.Magnetic resonance in medicine · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
purposeWe investigated the feasibility of quantitative susceptibility mapping (QSM) for assessing degradation of articular cartilage by measuring ex vivo bovine cartilage samples subjected to different degradative treatments. Specimens were scanned at several orientations to study if degradation affects the susceptibility anisotropy. T2*-mapping, histological stainings, and polarized light microscopy were used as reference methods. Additionally, simulations of susceptibility in layered geometry were performed.
methodsSamples (n = 9) were harvested from the patellae of skeletally mature bovines. Three specimens served as controls, and the rest were artificially degraded. MRI was performed at 9.4T using a 3D gradient echo sequence. QSM and T2* images and depth profiles through the centers of the samples were compared with each other and the histological findings. A planar isotropic model with depth-wise susceptibility variation was used in the simulations.
resultsA strong diamagnetic contrast was seen in the deep and calcified layers of cartilage, while T2* maps reflected the typical trilaminar structure of the collagen network. Anisotropy of susceptibility in cartilage was observed and was found to differ from the T2* anisotropy. Slight changes were observed in QSM and T2* following the degradative treatments. In simulations, anisotropy was observed.
conclusionsThe results suggest that QSM is not sensitive to cartilage proteoglycan content, but shows sensitivity to the amount of calcification and to the integrity of the collagen network, providing potential for assessing osteoarthritis. The simulations suggested that the anisotropy of susceptibility might be partially explained by the layered geometry of susceptibility in cartilage.
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