Evidence map›Paper›PMID 29687890›Full record

ReviewComprehensive Physiology2018

Intestinal CD36 and Other Key Proteins of Lipid Utilization: Role in Absorption and Gut Homeostasis.

Vincenza Cifarelli, Nada A Abumrad

Open access · greenAbstract readReview
In one paragraph

Review in Comprehensive Physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 94 citations in OpenAlex.

  1. Review
  2. Article
  3. Functional segregation of body-brain signals in the area postrema.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Dietary Lipids and Their Metabolism in the Midgut.Advances in experimental medicine and biology · 2026
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Regulation of lipid storage and inflammation in the liver by CEACAM1.European journal of clinical investigation · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vincenza CifarelliDepartment of Internal Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA.
Nada A AbumradDepartment of Internal Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA.
Washington University in St. Louis · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
CD36 AND INTESTINAL FAT ABSORPTIONR01DK060022 · NIDDK · WASHINGTON UNIVERSITY · PI ABUMRAD, NADA A. · 2001 to 2021
$7.7M
CARDIOVASCULAR SYSTEM--FUNCTION/REGULATION/PHARMACOLOGYT32HL007275 · NHLBI · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M. · 1985 to 2013
$6.0M
FATTY ACID TRANSPORTER: REGULATION, IDENTIFICATIONR01DK033301 · NIDDK · WASHINGTON UNIVERSITY · PI ABUMRAD, NADA A. · 1986 to 2017
$5.2M
ROLE OF CD36 IN NUTRIENT DELIVERY AND ITS DYSFUNCTION IN AFRICAN AMERICANSR01DK111175 · NIDDK · WASHINGTON UNIVERSITY · PI ABUMRAD, NADA A., ABUMRAD, NAJI N · 2016 to 2019
$1.9M
NHLBI NIH HHS T32 HL007275NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK033301NIDDK NIH HHS R01 DK060022NIDDK NIH HHS R01 DK111175
6 · The paper itself

Abstract

Several proteins have been implicated in fatty acid (FA) transport by enterocytes including the scavenger receptor CD36 (SR-B2), the scavenger receptor B1 (SR-B1) a member of the CD36 family and the FA transport protein 4 (FATP4). Here, we review the regulation of enterocyte FA uptake and its function in lipid absorption including prechylomicron formation, assembly and transport. Emphasis is given to CD36, which is abundantly expressed along the digestive tract of rodents and humans and has been the most studied. We also address the pleiotropic functions of CD36 that go beyond lipid absorption and metabolism to include recent evidence of its impact on intestinal homeostasis and barrier maintenance. Areas of progress involving contribution of membrane phospholipid remodeling and of cytosolic FA-binding proteins, FABP1 and FABP2 to fat absorption will be covered. © 2018 American Physiological Society. Compr Physiol 8:493-507, 2018.

Indexed as

AnimalsBiological TransportCD36 AntigensChylomicronsDigestive SystemEnterocytesFatty AcidsHomeostasisHumansIntestinal AbsorptionLipid MetabolismPhospholipidsCD36 AntigensChylomicronsFatty AcidsPhospholipids

Identifiers

PMID29687890
PMCPMC6247794
OpenAlexW2889193657

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.