ArticleJournal of neurovirology2018
Basal ganglia shrinkage without remarkable hippocampal atrophy in chronic aviremic HIV-positive patients.
Article in Journal of neurovirology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Different roles of frontal versus striatal atrophy in HIV-associated neurocognitive disorders.Human brain mapping · 2019Pooled it
- HIV-Associated Neurocognitive Disorder (HAND) and Alzheimer's Disease Pathogenesis: Future Directions for Diagnosis and Treatment.International journal of molecular sciences · 2024Review
- Additive Effect of Metabolic Syndrome on Brain Atrophy in People Living with HIV-Magnetic Resonance Volumetry Study.Metabolites · 2024Article
- Brain function abnormalities and neuroinflammation in people living with HIV-associated anxiety disorders.Frontiers in psychiatry · 2024Article
- Unveiling neuroimmunology profile of immunological non-responders in HIV: a multimodal MRI approach.Frontiers in immunology · 2024Article
- Imaging of Brain Structural and Functional Effects in People With Human Immunodeficiency Virus.The Journal of infectious diseases · 2023Review
- Additive cortical gray matter deficits in people living with HIV who use cocaine.Journal of neurovirology · 2023Article
- Neurofunctional characteristics of executive control in older people with HIV infection: a comparison with Parkinson's disease.Brain imaging and behavior · 2022Article
- Differential Effects of AIDS and Chronic Human Immunodeficiency Virus Infection on Gray Matter Volume.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Alterations of Brain Signal Oscillations in Older Individuals with HIV Infection and Parkinson's Disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- Early prediction of putamen imaging features in HIV-associated neurocognitive impairment syndrome.BMC neurology · 2021Article
- Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool.Frontiers in neuroscience · 2021Article
- Brain amyloid in virally suppressed HIV-associated neurocognitive disorder.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease.Frontiers in aging neuroscience · 2020Article
- Longitudinal brain atrophy patterns and neuropsychological performance in older adults with HIV-associated neurocognitive disorder compared with early Alzheimer's disease.Neurobiology of aging · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional magnetic-resonance (MR) imaging is not sensitive enough in depicting subtle neurodegenerative changes that occur during chronic HIV infection with good peripheral viral suppression. The aim of this study was to compare brain volumes in HIV-positive subjects with age- and education-matched healthy controls with regard to influence of aging and immunologic parameters. An overall of 65 subjects (40 HIV-positive and 25 age-, gender-, and education-matched healthy subjects) underwent conventional MR imaging with three-dimensional sequence adequate for volumetric measurements. Volumes of specific brain regions were measured and compared between HIV-positive and healthy subjects using Student t test. Correlations between obtained brain volumes and immunologic parameters were determined using Pearson's correlation test. Influence of age as a covariate was determined using ANCOVA test. Statistical value was set at p < 0.05. Volumes of nucleus accumbens (p = 0.003), putamen (p = 0.003), and thalamus (p = 0.046) were significantly decreased in HIV-positive subjects compared with healthy, while volumes of lateral ventricles were significantly increased (p = 0.043). However, influence of age on atrophy was greater than presence of HIV infection in all observed volumes. Positive correlation of nadir CD4+ count and nucleus accumbens volume was obtained, as well as of therapy with lateral ventricle volumes. Volumes of putamen correlated negatively with duration of therapy. HIV-associated atrophic changes are visible in nucleus accumbens, putamen, and thalamus in neurocognitively asymptomatic stage, while no changes can be observed in the hippocampus, affected by other types of dementias. Under therapy, the influence of physiological aging on HIV-associated atrophy is greater than the presence of HIV infection per se.
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Registered trials
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