ArticleJournal of neurovirology2018
Structural connectome differences in HIV infection: brain network segregation associated with nadir CD4 cell count.
Article in Journal of neurovirology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Diffusion tensor imaging-functional MRI fusion reveals disrupted white matter structure-function coupling in HIV-associated asymptomatic neurocognitive impairment.Frontiers in neuroscience · 2026Article
- Decoding HIV-associated neurocognitive disorders: a new perspective from multimodal connectomics.Frontiers in neurology · 2025Review
- Neuroimaging advances in neurocognitive disorders among HIV-infected individuals.Frontiers in neurology · 2025Review
- Reduced white matter maturation in the central auditory system of children living with HIV.Frontiers in neuroimaging · 2024Article
- Multishell diffusion MRI reveals whole-brain white matter changes in HIV.Human brain mapping · 2023Article
- Altered gray matter structural covariance networks in drug-naïve and treated early HIV-infected individuals.Frontiers in neurology · 2022Article
- Rich-Club Analysis of Structural Brain Network Alterations in HIV Positive Patients With Fully Suppressed Plasma Viral Loads.Frontiers in neurology · 2022Article
- Human immunodeficiency virus-related decreases in corpus callosal integrity and corresponding increases in functional connectivity.Human brain mapping · 2021Article
- Genetic Influence Underlying Brain Connectivity Phenotype: A Study on Two Age-Specific Cohorts.Frontiers in genetics · 2021Article
- Whole-brain computational modeling reveals disruption of microscale brain dynamics in HIV infected individuals.Human brain mapping · 2021Article
- Diffusion tensor magnetic resonance imaging of white matter integrity in patients with HIV-associated neurocognitive disorders.Annals of translational medicine · 2020Article
- Changes in resting-state functional brain activity are associated with waning cognitive functions in HIV-infected children.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
This study investigated structural brain organization using diffusion tensor imaging (DTI) in 35 HIV-positive and 35 HIV-negative individuals. We used global and nodal graph theory metrics to investigate whether HIV was associated with differences in brain network organization based on fractional anisotropy (FA) and mean diffusivity (MD). Participants also completed a comprehensive neuropsychological testing battery. For global network metrics, HIV-positive individuals displayed a lower FA clustering coefficient relative to HIV-negative individuals. For nodal network metrics, HIV-positive individuals had less MD nodal degree in the left thalamus. Within HIV-positive individuals, the FA global clustering coefficient was positively correlated with nadir CD4 cell count. Across the sample, cognitive performance was negatively correlated with characteristic path length and positively correlated with global efficiency for FA. These results suggest that, despite management with combination antiretroviral therapy, HIV infection is associated with altered structural brain network segregation and thalamic centrality and that low nadir CD4 cell count may be a risk factor. These graph theory metrics may serve as neural biomarkers to identify individuals at risk for HIV-related neurological complications.
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Registered trials
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