ArticleMolecular imaging and biology2018
Optimization of a Labeling and Kit Preparation Method for Ga-68 Labeled DOTATATE, Using Cation Exchange Resin Purified Ga-68 Eluates Obtained from a Tin Dioxide
Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- ScalableWorld journal of nuclear medicine · 2026Article
- Prospective Multicentric Assessment ofCancers · 2023Article
- Good practices forEJNMMI radiopharmacy and chemistry · 2022Review
- Translating a radiolabeled imaging agent to the clinic.Advanced drug delivery reviews · 2022Review
- Towards Facile Radiolabeling and Preparation of Gallium-68-/Bismuth-213-DOTA-[ThiPharmaceutics · 2021Article
- Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality.Pharmaceuticals (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to optimize a radiolabeling method using cationic processed Ga-68 eluates from a SnO PROCEDURES: Diluted generator eluates were adsorbed on a SCX resin and desorbed with acidified 5 M NaCl solution. Optimized labeling conditions were determined by variation of pH, using 35 μg DOTATATE and sodium acetate buffer. DOTATATE kits were developed based on optimized radiolabeling conditions, were labeled, and evaluated.
resultsOptimized labeling conditions resulted in a radiolabeling efficiency of around 99 % and radiochemical yield of almost 85 %. Different kit preparation methods did not significantly influence the radiolabeling results. Kits were found to be stable over 3 months.
conclusionA labeling method using SCX-processed Ga-68 eluates was optimized. DOTATATE kits specifically for these SCX-processed Ga-68 eluates were successfully formulated. A post-labeling Sep-Pak C18 purification should be optional.
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Registered trials
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