Evidence map›Paper›PMID 29687308›Full record

ArticleNeurochemical research2018

Exposure to Far Infrared Ray Protects Methamphetamine-Induced Behavioral Sensitization in Glutathione Peroxidase-1 Knockout Mice via Attenuating Mitochondrial Burdens and Dopamine D1 Receptor Activation.

Huynh Nhu Mai, Naveen Sharma, Eun-Joo Shin, Bao Trong Nguyen, Ji Hoon Jeong, Choon-Gon Jang, Eun-Hee Cho, Seung Yeol Nah, Nam Hun Kim, Toshitaka Nabeshima and 1 more

Abstract read
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In one paragraph

Article in Neurochemical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Huynh Nhu MaiNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Naveen SharmaNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Eun-Joo ShinNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Bao Trong NguyenNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Ji Hoon JeongDepartment of Pharmacology, College of Medicine, Chung-Ang University, Seoul, 06974, Republic of Korea.
Choon-Gon JangDepartment of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Eun-Hee ChoDepartment of Internal Medicine, Medical School, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Seung Yeol NahGinsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea.
Nam Hun KimCollege of Forest and Environmental Sciences, Kangwon National University, Chuncheon, 24341, Republic of Korea. kimnh@kangwon.ac.kr.
Toshitaka NabeshimaAdvanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Sciences, Aichi, 470-1192, Japan.
Hyoung-Chun KimNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea. kimhc@kangwon.ac.kr.ORCID http://orcid.org/0000-0003-0420-795X
Kangwon National University · KRChung-Ang University · KRFujita Health University · JPKonkuk University · KRSungkyunkwan University · KR

Funding

Korea Food and Drug Administration 14182MFDS979Korea Forest Service S111616L040110
6 · The paper itself

Abstract

Evidence indicates that stress conditions might lead to drug dependence. Recently, we have demonstrated that exposure to far infrared ray (FIR) attenuates acute restraint stress via induction of glutathione peroxidase-1 (GPx-1) gene. We investigated whether FIR affects methamphetamine (MA)-induced behavioral sensitization and whether FIR-mediated pharmacological activity requires interaction between dopamine receptor and GPx-1 gene. We observed that MA treatment significantly increased GPx-1 expression in the striatum of wild-type (WT) mice. Interestingly, exposure to FIR potentiated MA-induced increase in GPx-1 expression. This phenomenon was also observed in animals receiving MA with dopamine D1 receptor antagonist SCH23390. However, dopamine D2 receptor antagonist sulpiride did not affect MA-induced GPx-1 expression. FIR exposure or SCH23390, but not sulpiride, significantly attenuated MA-induced behavioral sensitization. Exposure to FIR significantly attenuated MA-induced dopamine D1 receptor expression, c-Fos induction and oxidative burdens. FIR-mediated antioxidant effects were also more pronounced in mitochondrial- than cytosolic-fraction. In addition, FIR significantly attenuated against MA-induced changes in mitochondrial superoxide dismutase and mitochondrial GPx activities, mitochondrial transmembrane potential, intramitochondrial Ca

Indexed as

Infrared RaysAnimalsAntioxidantsBehavior, AnimalBenzazepinesCentral Nervous System StimulantsDopamine AntagonistsGlutathione PeroxidaseGlutathione Peroxidase GPX1MaleMembrane Potential, MitochondrialMethamphetamineMiceMice, Inbred C57BLMice, KnockoutMitochondriaAntioxidantsBenzazepinesCentral Nervous System StimulantsDopamine AntagonistsDrd1 protein, mouseGlutathione PeroxidaseGlutathione Peroxidase GPX1Gpx1 protein, mouseMethamphetamineReceptors, Dopamine D1SCH 23390Dopamine D1 receptorFar infrared rayGlutathione peroxidase-1 knockout miceMethamphetamine-induced behavioral sensitizationMitochondrial burdensStriatum

Identifiers

PMID29687308
OpenAlexW2800377247

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.