Evidence map›Paper›PMID 29687234›Full record

ReviewCellular and molecular neurobiology2018

ROS as Regulators of Mitochondrial Dynamics in Neurons.

Carolina Cid-Castro, Diego Rolando Hernández-Espinosa, Julio Morán

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 107 citations in OpenAlex.

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  12. Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
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  13. Review
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  17. Water Extract ofInternational journal of molecular sciences · 2023
    Article
  18. Article
  19. AMPK/MFF Activation: Role in Mitochondrial Fission and Mitophagy in Dry Eye.Investigative ophthalmology & visual science · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Carolina Cid-CastroDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-253, 04510, Mexico, DF, Mexico.
Diego Rolando Hernández-EspinosaDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-253, 04510, Mexico, DF, Mexico.
Julio MoránDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-253, 04510, Mexico, DF, Mexico. jmoran@ifc.unam.mx.ORCID http://orcid.org/0000-0003-4880-8597
Universidad Nacional Autónoma de México · MX

Funding

Consejo Nacional de Ciencia y Tecnología 285184PAPIIT-DGAPA , UNAM IN210716
6 · The paper itself

Abstract

Mitochondrial dynamics is a complex process, which involves the fission and fusion of mitochondrial outer and inner membranes. These processes organize the mitochondrial size and morphology, as well as their localization throughout the cells. In the last two decades, it has become a spotlight due to their importance in the pathophysiological processes, particularly in neurological diseases. It is known that Drp1, mitofusin 1 and 2, and Opa1 constitute the core of proteins that coordinate this intricate and dynamic process. Likewise, changes in the levels of reactive oxygen species (ROS) lead to modifications in the expression and/or activity of the proteins implicated in the mitochondrial dynamics, suggesting an involvement of these molecules in the process. In this review, we discuss the role of ROS in the regulation of fusion/fission in the nervous system, as well as the involvement of mitochondrial dynamics proteins in neurodegenerative diseases.

Indexed as

Mitochondrial DynamicsAnimalsHumansModels, BiologicalNervous SystemNeuronsReactive Oxygen SpeciesReactive Oxygen SpeciesCell deathMitochondrial dynamicsNeurodegenerative diseasesNeuronsROS

Identifiers

PMID29687234
PMCPMC11481975
OpenAlexW2801830041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.