Evidence map›Paper›PMID 29687231›Full record

ArticleCancer immunology, immunotherapy : CII2018

The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions.

Tong Zhang, Xiaomin Song, Lanlan Xu, Jie Ma, Yanjuan Zhang, Wenfeng Gong, Yilu Zhang, Xiaosui Zhou, Zuobai Wang, Yali Wang and 13 more

3 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 209 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 7 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05299476 phase2completednot on this mapstarted 2022, after this paper: background citation

A Single-arm, Open Phase II Trial of CAPOX Combined With Bevacizumab Combined With Tislelizumab in First-line Treatment of PDL1 CPS < 5 Locally Advanced or Metastati Gastroesophageal Adenocarcinoma

TypeinterventionalSponsorChinese PLA General HospitalRan2022 to 2025Enrolled32ConditionsAdvanced Gastroesophageal Adenocarcinoma, First-line Therapy, PDL1 CPS < 5ArmsCAPOX combined with bevacizumab and Tislelizumab
NCT05844371 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Clinical Efficacy and Safety of Adjuvant Immunotherapy (Tirelizumab) Plus Chemotherapy Versus Adjuvant Chemotherapy Alone in Lymph Node Positive Patients With Gastric Cancer After D2 Radical Resection

TypeinterventionalSponsorYixing People's HospitalRan2021 to 2024Enrolled60ConditionsGastric CancerArmstirelizumab, chemotherapy with oxaliplatin + heroda
NCT06940388 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer: An Open-label Randomized Controlled Phase II Study (The TOTAL Trial)

TypeinterventionalSponsorbrenner baruchRan2025 to 2030Enrolled134ConditionsLocally Advanced Rectal Cancer (LARC)ArmsTislelizumab, Total neoadjuvant therapy (TNT)
3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 7 syntheses or guidelines pooled it, 279 citations in OpenAlex.

  1. Hyperprogressive disease in carcinoma induced by immune checkpoint inhibitor therapy: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 1 institution in 1 country.

Tong ZhangBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Xiaomin SongBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Lanlan XuBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Jie MaBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Yanjuan ZhangBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Wenfeng GongBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Yilu ZhangBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Xiaosui ZhouBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Zuobai WangBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Yali WangBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Yingdi ShiBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Huichen BaiBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Ning LiuBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Xiaolong YangBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Xinxin CuiBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Yanping CaoBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Qi LiuBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Jing SongBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Yucheng LiBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Zhiyu TangBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Mingming GuoBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Lai WangBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China.
Kang LiBeiGene (Beijing) Co., Ltd., No. 30 Science Park Road, Zhong-Guan-Cun Life Science Park, Changping District, Beijing, 102206, People's Republic of China. kang.li@beigene.com.
BeiGene (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibodies targeting PD-1 have been demonstrated durable anti-cancer activity in certain cancer types. However, the anti-PD-1 antibodies are less or not efficacious in many situations, which might be attributed to co-expression of multiple inhibitory receptors or presence of immunosuppressive cells in the tumor microenvironment. Most of the anti-PD-1 antibodies used in clinical studies are of IgG4 isotype with the S228P mutation (IgG4

Indexed as

AnimalsAntibodies, MonoclonalApoptosisCarcinoma, Squamous CellCell ProliferationHumansImmunoglobulin GLymphocyte ActivationMacrophagesMiceMice, Inbred NODMice, SCIDProgrammed Cell Death 1 ReceptorReceptors, IgGSkin NeoplasmsT-LymphocytesAntibodies, MonoclonalImmunoglobulin GProgrammed Cell Death 1 ReceptorReceptors, IgGAntibodyCancer therapyFcγRIMacrophagesPD-1

Identifiers

PMID29687231
PMCPMC6006217
OpenAlexW2799565954

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.