ArticleJournal of the Association for Research in Otolaryngology : JARO2018
Mechanism Underlying the Effects of Estrogen Deficiency on Otoconia.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Sex and Gender Aspects in Vestibular Disorders: Current Knowledge and Emerging Perspectives-A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Otolith Deterioration: Factors Affecting Microvascular and Structural Integrity.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Association between amblyopia and benign paroxysmal positional vertigo: nationwide cohort study.Scientific reports · 2025Article
- Development of the semicircular canals and otolithic organs of the vertebrate inner ear.Current topics in developmental biology · 2025Review
- Enhancing patient care in BPPV-related residual dizziness: introducing the CLEAR algorithm to support BPPV-RD recognition and follow-up strategies.Frontiers in neurology · 2025Review
- The Impact of Serums Calcium 25-Hydroxy Vitamin D, Ferritin, Uric Acid, and Sleeping Disorders on Benign Paroxysmal Positional Vertigo Patients.Audiology research · 2024Article
- The Impact of Resistance Training on Equilibrium Abilities and Quality of Life in Older Adults after SARS-CoV-2 Survival.Journal of clinical medicine · 2024Article
- Review
- Pediatric Benign Paroxysmal Positional Vertigo: Degree of Nystagmus and Concurrent Dizziness Differs from Adult BPPV.Journal of clinical medicine · 2024Article
- Assessment of Osteoporosis and Vitamin D3 Deficiency in Patients with Idiopathic Benign Paroxysmal Positional Vertigo (BPPV).Medicina (Kaunas, Lithuania) · 2023Article
- Vestibular Disorders and Hormonal Dysregulations: State of the Art and Clinical Perspectives.Cells · 2023Review
- Effect of hormonal therapy on the otoconial changes caused by estrogen deficiency.Scientific reports · 2022Article
- Association of Serum Calcium and Vitamin D with Benign Paroxysmal Positional Vertigo.International archives of otorhinolaryngology · 2022Article
- Hormones and Vestibular Disorders: The Quest for Biomarkers.Brain sciences · 2022Article
- Advances in otolith-related protein research.Frontiers in neuroscience · 2022Review
- Causes and treatment of idiopathic benign paroxysmal positional vertigo based on endocrinological and other metabolic factors.Journal of otology · 2020Review
- Association between benign paroxysmal positional vertigo and osteoporosis: two nested case-control studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Review of the pathology underlying benign paroxysmal positional vertigo.The Journal of international medical research · 2020Article
- Auditory function and dysfunction: estrogen makes a difference.Cellular and molecular life sciences : CMLS · 2020Review
- Otopetrin-2 Immunolocalization in the Human Macula Utricle.The Annals of otology, rhinology, and laryngology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Otoconia-related vertigo and balance deficits, particularly benign paroxysmal positional vertigo (BPPV), are common. Our recent studies in humans show that, while BPPV prevalence greatly increases with age in both genders, peri-menopausal women are especially susceptible. In the present study, we show that bilateral ovariectomized (OVX) mice have significant balance behavioral deficits, and that estrogen deficiency compromises otoconia maintenance and anchoring by reducing the expression of otoconial component and anchoring proteins. There is ectopic debris formation in the ampulla under estrogen deficiency due to aberrant matrix protein expression. Furthermore, phytoestrogen is effective in rescuing the otoconia abnormalities. By comparing the expression levels of known estrogen receptor (Esr) subtypes, and by examining the otoconia phenotypes of null mice for selected receptors, we postulate that Esr2 may be critical in mediating the effects of estrogen in otoconia maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.