Evidence map›Paper›PMID 29687155›Full record

ArticleRheumatology international2018

Takayasu arteritis in childhood: misdiagnoses at disease onset and associated diseases.

Gleice Clemente, Clovis A Silva, Silvana B Sacchetti, Virginia P L Ferriani, Sheila K Oliveira, Flavio Sztajnbok, Blanca E R G Bica, André Cavalcanti, Teresa Robazzi, Marcia Bandeira and 1 more

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In one paragraph

Article in Rheumatology international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Review
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  12. Review
  13. Patterns of clinical presentation in Takayasu's arteritis.Seminars in arthritis and rheumatism · 2020
    Article
  14. Article
  15. Childhood-onset Takayasu Arteritis.European journal of rheumatology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 1 country.

Gleice ClementePediatrics Rheumatoloy Unit, Department of Pediatrics, São Paulo Federal University, São Paulo, SP, Brazil. gleiceclemente@gmail.com.ORCID http://orcid.org/0000-0001-7824-437X
Clovis A SilvaPediatrics Rheumatology Unit, Children's Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-9250-6508
Silvana B SacchettiPediatrics Rheumatology Unit, Pediatric Department of Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-5466-9063
Virginia P L FerrianiPediatrics Rheumatology Division, Department of Pediatrics, Ribeirao Preto Medical School, Sao Paulo University, Ribeirao Preto, SP, Brazil.ORCID http://orcid.org/0000-0002-9555-9389
Sheila K OliveiraPediatric Rheumatology Unit, Rio de Janeiro Federal University (IPPMG-UFRJ), Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0002-2426-716X
Flavio SztajnbokPediatric Rheumatology Unit, Pedro Ernesto University Hospital, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0002-7301-9664
Blanca E R G BicaHospital Universitário Clementino Fraga Filho-Rheumatology Division-Rio de Janeiro Federal University, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0002-6927-6617
André CavalcantiPediatrics Rheumatology Unit, Department of Materno-Infantil, Federal University of Pernambuco, Recife, PE, Brazil.ORCID http://orcid.org/0000-0002-9105-3153
Teresa RobazziPediatrics Rheumatology Unit, Bahia Federal University, Salvador, BA, Brazil.ORCID http://orcid.org/0000-0001-5484-3853
Marcia BandeiraPequeno Príncipe Hospital, Curitiba, PR, Brazil.ORCID http://orcid.org/0000-0001-5001-3916
Maria Teresa TerreriPediatrics Rheumatoloy Unit, Department of Pediatrics, São Paulo Federal University, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-2496-4296
Universidade Federal de São Paulo · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRHospital Universitário Clementino Fraga Filho · BRHospital Universitário Pedro Ernesto · BRIrmandade da Santa Casa de Misericórdia de São Paulo · BRUniversidade de São Paulo · BRUniversidade Federal da Bahia · BRUniversidade Federal de Pernambuco · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Juvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses. The most common of them was aortic coarctation in six (8.4%) patients, followed by rheumatic fever in five (7.0%) and one patient presented with both former diagnoses. Limb pain (two patients), spondyloarthropathy, juvenile idiopathic arthritis (JIA), spinal arteriovenous malformation, polyarteritis nodosa (PAN) and fever of unknown origin (FUO) were other misdiagnoses. Patients who had misdiagnoses previously to j-TA diagnosis presented a trend to have a longer diagnosis delay. 11 (15.5%) patients had 14 TA-associated diseases, such as pulmonary tuberculosis (5 patients), rheumatic fever (2 patients), spondyloarthropathy, polyarticular JIA, Crohn's disease, Prader-Willi disease, diabetes mellitus, Moyamoya and primary immunodeficiency. 7 (9.9%) patients presented 10 atypical manifestations, such as pyoderma gangrenosum, erythema nodosum, myositis, chorea, enthesitis, episcleritis, uveitis, hepatomegaly, splenomegaly and necrosis of extremities. Our study emphasizes the main misdiagnoses, associated diseases and atypical manifestations that occur in patients with j-TA and warns of the features that may alert paediatricians to this diagnosis, such as constitutional symptoms and elevated inflammatory markers.

Indexed as

AdolescentBrazilChildDiagnosis, DifferentialDiagnostic ErrorsFemaleHumansMalePolyarteritis NodosaRetrospective StudiesTakayasu ArteritisAdolescentChildhoodDiagnosisTakayasu arteritisVasculitis

Identifiers

PMID29687155
OpenAlexW2801751497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.