ArticleSurgery today2018
The use of broad-spectrum antibiotics reduces the incidence of surgical site infection after pancreatoduodenectomy.
Article in Surgery today, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Piperacillin/tazobactam for surgical prophylaxis during pancreatoduodenectomy: meta-analysis.BJS open · 2024Pooled it
- Guidelines for Perioperative Care for Pancreatoduodenectomy: Enhanced Recovery After Surgery (ERAS) Recommendations 2019.World journal of surgery · 2020Pooled it
- Perioperative antibiotics covering bacteriobilia reduce organ/space surgical site infection after pancreaticoduodenectomy with preoperative biliary drainage.Updates in surgery · 2026Article
- Impact of Prophylactic Cefepime on Surgical Site Infection and Severe Morbidity in Patients Who Underwent Pancreaticoduodenectomy With Preoperative Biliary Drainage.Annals of gastroenterological surgery · 2026Article
- Turning the tide in the mitigation of clinically relevant post-operative pancreatic fistula in pancreatoduodenectomy-broad-spectrum antibiotic surgical prophylaxis is the new standard of care.Hepatobiliary surgery and nutrition · 2026Article
- Antibiotic Resistance Patterns in Pancreatic Surgery: A Tailor-Made Antibiotic Prophylaxis in a Secondary Hospital.Cureus · 2026Article
- Impact of Wound Protectors on Complications Following Pancreaticoduodenectomy: A National Surgical Quality Improvement Program Analysis of 20 960 Patients.Journal of surgical oncology · 2025Article
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- Article
- Tailored Pre-Operative Antibiotic Prophylaxis to Prevent Post-Operative Surgical Site Infections in General Surgery.Antibiotics (Basel, Switzerland) · 2024Review
- Risk factors and outcomes for cholangitis after hepatic resection.Langenbeck's archives of surgery · 2023Article
- Impact of Extended Antibiotic Use After Pancreaticoduodenectomy for Patients with Preoperative Metallic Biliary Stenting Treated with Neoadjuvant Chemotherapy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Surgical Site Infections in Patients of Periampullary Carcinoma Undergoing Delayed Bile Duct Division (COMBILAST) in Whipple's Procedure: A Prospective Cohort Study.Pathogens (Basel, Switzerland) · 2023Article
- Antibiotic Prophylaxis for Hepato-Biliopancreatic Surgery-A Systematic Review.Antibiotics (Basel, Switzerland) · 2022Review
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe development of surgical site infection (SSI) after biliary reconstruction is highly influenced by the presence of preoperative bacteria in the bile juice. We selected vancomycin and piperacillin/tazobactam (VCM + PIPC/TAZ) as perioperative prophylactic antibiotics for patients undergoing pancreaticoduodenectomy. This study aimed to retrospectively analyze the effectiveness of VCM + PIPC/TAZ compared to cefmetazole.
methodsSeventy-two patients who underwent pancreaticoduodenectomy between April 2015 and March 2017 at our department were evaluated. Forty patients were administered cefmetazole as the perioperative prophylactic antibiotic, and 32 were administered VCM + PIPC/TAZ. The intraoperative VCM blood concentration (incision, biliary reconstruction, and wound closure) was measured during surgery to confirm the hemodynamics.
resultsThe frequency of SSIs was significantly lower in the VCM + PIPC/TAZ group (8/32 patients) than in the cefmetazole group (20/40 patients, P = 0.031). Postoperatively, significantly fewer patients in the VCM + PIPC/TAZ group (4/32 patients) required ≥ 15 days of additional antibiotic administration compared to those in the cefmetazole group (14/40 patients, P = 0.033). Six of 32 patients in the VCM + PIPC/TAZ group showed redneck syndrome symptoms. There was no significant difference in the VCM blood concentration between patients with and without SSIs.
conclusionsThe use of VCM + PIPC/TAZ can reduce the incidence of SSI after pancreaticoduodenectomy and also reduce the need for the additional administration of antibiotics for ≥ 15 days after surgery.
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