ArticleJournal of the Endocrine Society2018
Circulating Spexin Levels Negatively Correlate With Age, BMI, Fasting Glucose, and Triglycerides in Healthy Adult Women.
Article in Journal of the Endocrine Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Investigation of Spexin Effects on Insulin-Dependent Pathway Genes in High-Glucose-Induced Insulin-Resistant C2C12 Myotubes.FASEB bioAdvances · 2026Article
- Unraveling the Potential Role of Spexin in Exercise-Induced Improvement of Cardiometabolic Health in Obesity and Diabetes.Current obesity reports · 2026Review
- Emerging roles of spexin in cardiovascular homeostasis.Frontiers in cardiovascular medicine · 2026Review
- Serum spexin levels in women with diminished ovarian reserve: a prospective case-control study.Frontiers in medicine · 2026Article
- Associations Between Circulating Spexin, Obesity, and Insulin Resistance in Korean Children and Adolescents.Nutrients · 2025Article
- Normalization of Spexin Levels in Patients with Obesity Submitted to Bariatric Surgery.Obesity surgery · 2024Article
- Role of Spexin in White Adipose Tissue Thermogenesis under Basal and Cold-Stimulated Conditions.International journal of molecular sciences · 2024Article
- Circulating Spexin Is Associated with Body Mass Index and Fat Mass but Not with Physical Activity and Psychological Parameters in Women across a Broad Body Weight Spectrum.Journal of clinical medicine · 2022Article
- Impact of spexin on metabolic diseases and inflammation: An updated minireview.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Circulating spexins in children with obesity: relation to cardiometabolic risk.European journal of clinical nutrition · 2022Article
- The Association of Serum Circulating Neuropeptide Q and Chemerin Levels with Cardiometabolic Risk Factors among Patients with Metabolic Syndrome.Biomolecules · 2021Article
- Novel insights on the role of spexin as a biomarker of obesity and related cardiometabolic disease.International journal of obesity (2005) · 2021Review
- Short-term changes and correlations of plasma spexin, kisspeptin, and galanin levels after laparoscopic sleeve gastrectomy.Surgery today · 2021Article
- Low levels of spexin and adiponectin may predict insulin resistance in patients with non-alcoholic fatty liver.Practical laboratory medicine · 2021Article
- Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour.Nature reviews. Endocrinology · 2021Review
- Insulin resistance and decreased spexin in Indian Patients with Type 2 Diabetes Mellitus.Bioinformation · 2021Article
- Spexin status in relation to obesity and its related comorbidities: a systematic review.Journal of diabetes and metabolic disorders · 2020Review
- Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes.Scientific reports · 2020Article
- Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Female Adolescents.Journal of clinical medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextSpexin is a newly identified neuropeptide that is involved in satiety control, glucose, and lipids metabolism. It has also been related to human diseases, such as obesity and type 2 diabetes. However, whether spexin changes with age or not is still unclear.
objectiveThe aim of this study is to investigate the relationship between circulating spexin levels and age and to study their interaction effects on body mass index (BMI), fasting glucose, and -lipids. DESIGN AND
participantsThis is a cross-sectional study, including 68 healthy adult women whose ages are in a wide range (minimum: 23; median: 38.5; maximum: 64). OUTCOME MEASURES: The serum spexin levels were measured by an enzyme-linked immunosorbent assay. Fasting glucose, total cholesterol, triglycerides (TG), alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, urea, and creatinine were measured by routine biochemical test. Shapiro-Wilk's test, Spearman and Pearson correlation analyses,
resultsSerum spexin levels are significantly correlated with age (Spearman
conclusionsCirculating spexin levels decrease with age, suggesting a possible role of this peptide in aging-related functions and disorders. Further investigations are needed to expand the clinical significance of this finding.
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