Evidence map›Paper›PMID 29687041›Full record

ReviewTemperature (Austin, Tex.)2018

Meta-inflammation and cardiometabolic disease in obesity: Can heat therapy help?

Brett R Ely, Zachary S Clayton, Carrie E McCurdy, Joshua Pfeiffer, Christopher T Minson

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Temperature (Austin, Tex.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  15. [Nutrigenetics: potentials and applications in cardiovascular diseases and associated risk factors].Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Brett R ElyDepartment of Human Physiology, University of Oregon, Eugene, OR, USA.ORCID 0000-0002-8062-4475
Zachary S ClaytonDepartment of Human Physiology, University of Oregon, Eugene, OR, USA.
Carrie E McCurdyDepartment of Human Physiology, University of Oregon, Eugene, OR, USA.ORCID 0000-0003-1177-9040
Joshua PfeifferPeace Health Medical Group, Oregon Bariatric Center, Springfield, OR, USA.
Christopher T MinsonDepartment of Human Physiology, University of Oregon, Eugene, OR, USA.ORCID 0000-0003-3459-3708
University of Oregon · US

Funding

Role of PIK3R1 in Adipose Tissue Insulin Resistance and Inflammation in ObesityR01DK095926 · NIDDK · UNIVERSITY OF OREGON · PI MCCURDY, CARRIE E · 2014 to 2018
$1.5M
NIDDK NIH HHS R01 DK095926
6 · The paper itself

Abstract

Obesity and associated metabolic dysfunction have reached epidemic proportions worldwide. The current theory linking metabolic disease and obesity involves ischemic adipose tissue initiating an inflammatory cascade that results in systemic insulin resistance and may eventually lead to type II diabetes mellitus. Diabetes and associated metabolic dysfunction increase the risk of developing cardiovascular disease and fatal cardiovascular events. By targeting key steps in this process, ischemia and inflammation, this cascade may be prevented or reversed and thus metabolic and cardiovascular health may be preserved in obesity. Regular heat exposure (termed 'heat therapy') offers potential to improve cardiometabolic health in obese individuals through a variety of mechanisms that include but are not limited to heat shock proteins, hypoxia-inducible factor 1α, and hemodynamic effects. The purpose of this review is to highlight the cardiometabolic decline in obese individuals stemming from adipose tissue dysfunction, and examine the ways in which heat therapy and associated cellular and systemic adaptations can intersect with this decline in function to improve or restore cardiovascular and metabolic health.

Indexed as

cardiovascular diseasediabetes mellitusheat acclimationheat shock proteinhyperthermic conditioninginsulin resistancesympathetic activitythermotherapy

Identifiers

PMID29687041
PMCPMC5902218
OpenAlexW2763874848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.