Evidence map›Paper›PMID 29687032›Full record

ArticleMolecular therapy. Methods & clinical development2018

Enhanced Expression of Anti-CD19 Chimeric Antigen Receptor in

Daisuke Morita, Nobuhiro Nishio, Shoji Saito, Miyuki Tanaka, Nozomu Kawashima, Yusuke Okuno, Satoshi Suzuki, Kazuyuki Matsuda, Yasuhiro Maeda, Matthew H Wilson and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 64 citations in OpenAlex.

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  8. CAR-T cell therapy: a game-changer in cancer treatment and beyond.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
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  17. Frontiers in immunology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Daisuke MoritaDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan.
Nobuhiro NishioCenter for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan.
Shoji SaitoDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan.
Miyuki TanakaDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan.
Nozomu KawashimaDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
Yusuke OkunoCenter for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan.
Satoshi SuzukiCenter for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Aichi 466-8560, Japan.
Kazuyuki MatsudaDepartment of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Nagano 390-8621, Japan.
Yasuhiro MaedaDepartment of Hematology, National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Osaka 586-8521, Japan.
Matthew H WilsonDepartment of Medicine, Vanderbilt University School of Medicine and VA Tennessee Valley Health Care, Nashville, TN 37232, USA.
Gianpietro DottiDepartment of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Cliona M RooneyCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Yoshiyuki TakahashiDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
Yozo NakazawaDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan.
Shinshu University · JPNagoya University · JPNagoya University Hospital · JPBaylor College of Medicine · USOsaka Minami Medical Center · JPShinshu University Hospital · JPUniversity of North Carolina at Chapel Hill · USVA Tennessee Valley Healthcare System · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Tissue ResourceP50CA126752 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, HELEN E HESLOP · 2007 to 2026
$51.4M
Novel cell therapy for sustained therapeutic protein delivery in vivoR01DK093660 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, MATTHEW H · 2012 to 2022
$3.4M
NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA126752NIDDK NIH HHS R01 DK093660
6 · The paper itself

Abstract

Adoptive T cell therapy using chimeric antigen receptor (CAR)-modified T cells is a promising cancer immunotherapy. We previously developed a non-viral method of gene transfer into T cells using a

Indexed as

acute lymphoblastic leukemiachimeric antigen receptornon-viral vectorpiggyBacrefractorytransposonvirus-specific antigens

Identifiers

PMID29687032
PMCPMC5907825
OpenAlexW2779236169

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.