ArticleAnnals of clinical and translational neurology2018
Diabetes and obesity are the main metabolic drivers of peripheral neuropathy.
Article in Annals of clinical and translational neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 6 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
112 citing papers in PubMed, 6 syntheses or guidelines pooled it, 189 citations in OpenAlex.
- The Relationship Between Prediabetes and Peripheral Neuropathy-A Systematic Review and Meta-Analysis.European journal of neurology · 2025Pooled it
- Mapping the research landscape of the interactions between obesity and five major complications of diabetes: a bibliometric analysis using knowledge graph visualization.Frontiers in endocrinology · 2025Pooled it
- American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022Guideline
- Prevalence of peripheral neuropathy in pre-diabetes: a systematic review.BMJ open diabetes research & care · 2021Pooled it
- A systematic review and meta-analysis of the serum lipid profile in prediction of diabetic neuropathy.Scientific reports · 2021Pooled it
- Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Comparison of intraepidermal nerve fiber density and confocal corneal microscopy for neuropathy.Annals of clinical and translational neurology · 2024Trial
- Longitudinal assessment of metabolic and neurological decline in peripheral polyneuropathy over ten years.Future science OA · 2026Article
- Diffusion tensor MR neurography reveals altered sciatic and tibial nerve microstructure in chronic dialysis patients.Clinical kidney journal · 2026Article
- NONcNZO10/LtJ and TALLY-HO/JngJ Mice as Novel Models of Diabetic Peripheral Neuropathy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Comparing the Diagnostic Characteristics of Neuropathy Questionnaires in Adults With Obesity.Journal of the peripheral nervous system : JPNS · 2026Article
- Body mass index and peripheral neuropathy across the glucose tolerance spectrum in Japanese adults.Journal of diabetes investigation · 2026Article
- Value of 2-Dimensional Shear-Wave Elastography in Assessing Tibial Nerve Stiffness in Diabetic Peripheral Neuropathy.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- The association between visceral fat indices and diabetic peripheral neuropathy in type 2 diabetes mellitus: A retrospective cross-sectional study.Turkish journal of physical medicine and rehabilitation · 2026Article
- Targeting risk factors and strategies for prevention of peripheral neuropathy: focus on B-vitamin deficiencies and metabolic diseases.Neurological research and practice · 2026Review
- Causal relationship between obesity and diabetic neuropathy: A 2-sample Mendelian randomization study.Medicine · 2026Article
- Association of static balance parameters with prediabetes: a cross-sectional study and nomogram development.Frontiers in endocrinology · 2026Observational
- Neurological manifestations in metabolic dysfunction syndrome are associated with cumulative metabolic burden beyond hyperglycaemia: a translational study.Frontiers in endocrinology · 2026Article
- Dietary monounsaturated fatty acids reduce nerve inflammation and improve nerve function in murine models of obesity.Frontiers in immunology · 2026Article
- Influence of Genomic Ancestry and Other Traditional Risk Factors on the Prevalence of Diabetic Peripheral Neuropathy in Admixed Individuals With Type 1 Diabetes in Brazil: A Pioneer Multicenter Study.Journal of the peripheral nervous system : JPNS · 2025Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo determine the associations between individual metabolic syndrome (MetS) components and peripheral neuropathy in a large population-based cohort from Pinggu, China.
methodsA cross-sectional, randomly selected, population-based survey of participants from Pinggu, China was performed. Metabolic phenotyping and neuropathy outcomes were performed by trained personnel. Glycemic status was defined according to the American Diabetes Association criteria, and the MetS using modified consensus criteria (body mass index instead of waist circumference). The primary peripheral neuropathy outcome was the Michigan Neuropathy Screening Instrument (MNSI) examination. Secondary outcomes were the MNSI questionnaire and monofilament testing. Multivariable models were used to assess for associations between individual MetS components and peripheral neuropathy. Tree-based methods were used to construct a classifier for peripheral neuropathy using demographics and MetS components.
resultsThe mean (SD) age of the 4002 participants was 51.6 (11.8) and 51.0% were male; 37.2% of the population had normoglycemia, 44.0% prediabetes, and 18.9% diabetes. The prevalence of peripheral neuropathy increased with worsening glycemic status (3.25% in normoglycemia, 6.29% in prediabetes, and 15.12% in diabetes,
interpretationSimilar to previous studies, diabetes and obesity are the main metabolic drivers of peripheral neuropathy. The consistency of these results reinforces the urgent need for effective interventions that target these metabolic factors to prevent and/or treat peripheral neuropathy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.