ArticleOpen forum infectious diseases2018
Dietary Patterns and Physical Activity Correlate With Total Cholesterol Independently of Lipid-Lowering Drugs and Antiretroviral Therapy in Aging People Living With Human Immunodeficiency Virus.
Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Trial
- Time Trends in Causes of Death in People With HIV: Insights From the Swiss HIV Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Joint temporal dietary and physical activity patterns: associations with health status indicators and chronic diseases.The American journal of clinical nutrition · 2022Article
- Article
- Contemporary Lifestyle Modification Interventions to Improve Metabolic Comorbidities in HIV.Current HIV/AIDS reports · 2019Review
- Evidence-informed practical recommendations for increasing physical activity among persons living with HIV.AIDS (London, England) · 2019Article
- Changes in Lipid Indices in HIV+ Cases on HAART.BioMed research international · 2019Article
- HIV-1 and Compromised Adult Neurogenesis: Emerging Evidence for a New Paradigm of HAND PersistenceAIDS reviews · 2019Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypercholesterolemia is a well established risk factor for coronary heart disease and is highly prevalent among human immunodeficiency virus (HIV)-positive persons. Antiretroviral therapy (ART) can both directly modify total cholesterol and have drug-drug interactions with statins. This makes investigating modifiable behavioral predictors of total cholesterol a pertinent task.
methodsTo explore the association between diet and physical activity with cross-sectionally measured total cholesterol, we administered a validated Food-Frequency-Questionnaire to participants of the Swiss HIV Cohort Study ≥45 years old. Linear mixed-effects models were applied to explore the associations between dietary patterns and physical activity with total cholesterol, after adjustment for clinical and demographic covariates.
resultsIn total, 395 patients were included. Forty percent (158 of 395) had elevated total cholesterol (>5.2 mmol/L), and 41% (164 of 395) were not regularly physically active. In multivariable analysis, 2 factors were positively associated with total cholesterol; female sex (β = 0.562; 95% confidence interval [CI], 0.229-0.896) and the combined consumption of meat, refined/milled grains, carbonated beverages, and coffee (β = 0.243; 95% CI, 0.047-0.439). On the other hand, regular physical activity (β = -0.381; 95% CI, -0.626 to -0.136), lipid-lowering drugs (β = -0.443; 95% CI -0.691 to -0.196), ART containing tenofovir (β = -0.336; 95% CI -0.554 to -0.118), and black ethnicity (β = -0.967; 95% CI -1.524 to -0.410) exhibited a negative association.
conclusionsWe found independent associations between certain dietary patterns and physical activity with total cholesterol. Increasing physical activity might achieve cardiovascular and other health benefits in HIV-positive individuals. The clinical relevance of the identified dietary patterns requires further investigation in prospective cohort studies and randomized controlled trials.
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