Evidence map›Paper›PMID 29686831›Full record

ArticleParkinson's disease2018

Microarray Analysis of the Molecular Mechanism Involved in Parkinson's Disease.

Cheng Tan, Xiaoyang Liu, Jiajun Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinson's disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cheng TanDepartment of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China.
Xiaoyang LiuDepartment of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China.
Jiajun ChenDepartment of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China.ORCID 0000-0003-1065-9952
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to investigate the underlying molecular mechanisms of Parkinson's disease (PD) by bioinformatics.

methodsUsing the microarray dataset GSE72267 from the Gene Expression Omnibus database, which included 40 blood samples from PD patients and 19 matched controls, differentially expressed genes (DEGs) were identified after data preprocessing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Protein-protein interaction (PPI) network, microRNA- (miRNA-) target regulatory network, and transcription factor- (TF-) target regulatory networks were constructed.

resultsOf 819 DEGs obtained, 359 were upregulated and 460 were downregulated. Two GO terms, "rRNA processing" and "cytoplasm," and two KEGG pathways, "metabolic pathways" and "TNF signaling pathway," played roles in PD development. Intercellular adhesion molecule 1 (

conclusions"rRNA processing," "cytoplasm," "metabolic pathways," and "TNF signaling pathway" were key pathways involved in PD.

Identifiers

PMID29686831
PMCPMC5852864
OpenAlexW2790341725

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.