Evidence map›Paper›PMID 29686818›Full record

ArticleEuropean journal of translational myology2018

Effects of combined endurance and resistance training in Amyotrophic Lateral Sclerosis: A pilot, randomized, controlled study.

Antonio Merico, Marianna Cavinato, Caterina Gregorio, Alessandra Lacatena, Elisabetta Gioia, Francesco Piccione, Corrado Angelini

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of translational myology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
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  4. Systematic Review of Therapeutic Physical Exercise in Patients with Amyotrophic Lateral Sclerosis over Time.International journal of environmental research and public health · 2021
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  12. Targeting mitochondrial CaThe Journal of physiology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Antonio MericoNeurorehabilitation Department, San Camillo Hospital Foundation, Institute of Care and Research, Venice. Italy.
Marianna CavinatoNeurorehabilitation Department, San Camillo Hospital Foundation, Institute of Care and Research, Venice. Italy.
Caterina GregorioDepartment of Economic, mathematical and statistical sciences, University of Trieste, Italy.
Alessandra LacatenaRehabilitation Department, Azienda Sanitaria Locale, Taranto, Italy.
Elisabetta GioiaRehabilitation Department, Unità Locale Socio-Sanitaria Serenissima, Venice, Italy.
Francesco PiccioneNeurorehabilitation Department, San Camillo Hospital Foundation, Institute of Care and Research, Venice. Italy.
Corrado AngeliniNeurorehabilitation Department, San Camillo Hospital Foundation, Institute of Care and Research, Venice. Italy.
ASL Roma · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on available evidence, muscle strengthening and cardiovascular exercises can help maintain function and not adversely affect the progression of disease in patients with ALS. However, this evidence is not sufficiently detailed to recommend a specific exercise prescription. The purpose of this project was to assess clinical outcomes of a combined exercise programme to increase knowledge of rehabilitation in ALS patients. 38 ALS patients were assigned randomly to two groups: one group underwent a specific exercise programme (ALS-EP) based on a moderate aerobic workout and isometric contractions, and the second group followed a standard neuromotor rehabilitation treatment. Objective evaluation consisted of cardiovascular measures, muscle strength and fatigue. Some positive effects of physical activity on ALS patients were found. Among the benefits, an overall improvement of functional independence in all patients, independently of the type of exercise conducted was seen. In addition, improvements in muscle power, oxygen consumption and fatigue were specifically observed in the ALS-EP group, all hallmarks of a training effect for the specific exercises. In conclusion, moderate intensity exercise is beneficial in ALS, helping in avoiding deconditioning and muscle atrophy resulting from progressive inactivity.

Indexed as

Amyotrophic Lateral Sclerosisendurance trainingisometric exerciseneurorehabilitation

Identifiers

PMID29686818
PMCPMC5895987
OpenAlexW2795170199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.