ReviewDiabetology & metabolic syndrome2018
Chikungunya and diabetes, what do we know?
Review in Diabetology & metabolic syndrome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Events preceding death among chikungunya virus infected patients: a systematic review.Revista da Sociedade Brasileira de Medicina Tropical · 2020Pooled it
- Perinatal outcomes of symptomatic chikungunya, dengue and Zika infection during pregnancy in Brazil: a registry-based cohort study.Nature communications · 2025Article
- Review
- Article
- Beyond the Bite: Detailed findings on Chikungunya and Dengue co-detection in Punjab, North India - clinical insights and diagnostic challenges.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Epidemiology and Economic Burden of Chikungunya: A Systematic Literature Review.Tropical medicine and infectious disease · 2023Review
- Article
- Role of Arbovirus Infection in Arthritogenic Pain Manifestation-A Systematic Review.Tropical medicine and infectious disease · 2022Review
- Article
- Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses' Outbreak in Rio de Janeiro, Brazil.Pathogens (Basel, Switzerland) · 2022Article
- Article
- Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries.Journal of biomedical science · 2021Review
- Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection.Frontiers in medicine · 2021Article
- The importance of physical activity in management of type 2 diabetes and COVID-19.Therapeutic advances in endocrinology and metabolism · 2021Review
- A brief analysis and hypotheses about the risk of COVID-19 for people with type 1 and type 2 diabetes mellitus.Journal of diabetes and metabolic disorders · 2020Article
- Local and scientific knowledge in the school context: characterization and content of published works.Journal of ethnobiology and ethnomedicine · 2020Article
- Chikungunya Case Classification after the Experience with Dengue Classification: How Much Time Will We Lose?The American journal of tropical medicine and hygiene · 2020Article
- Estimated mortality rate and leading causes of death among individuals with chikungunya in 2016 and 2017 in Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2020Observational
- Resveratrol alleviates ischemia/reperfusion injury of diabetic myocardium via inducing autophagy.Experimental and therapeutic medicine · 2019Article
- Maternal and infant death after probable vertical transmission of chikungunya virus in Brazil - case report.BMC infectious diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChikungunya (CHIK) is a viral disease transmitted by mosquitoes. The first cases in Brazil were confirmed in 2014. Between 2016 and 2017, over 300,000 cases were identified during this period, with nearly 300 deaths. The clinical manifestations, pathogenesis and risk factors for occurrence of severe cases are not yet well understood, although it is known that the severity of the cases is associated with the presence of comorbidities, especially diabetes mellitus (DM).
objectiveTo review the medical literature for the associations between DM and CHIK and to understand the potential impact on metabolic state and its complications.
methodsLiterature review was carried out to search for articles (English, Portuguese and Spanish) in Medline and Virtual Health Library databases for the period between 1952 and 2017, with the following keywords: "Chikungunya fever", "Chikungunya virus", "diabetes mellitus", "diabetes", "diabetes complications "and "multi-morbidities (MeSH) "with interposition of the Boolean operator "AND".
resultsAfter removal of duplicities and following exclusion criteria, 11 articles were selected. Our results showed that the patients of CHIK with DM had more severe and prolonged symptoms of CHIK and more frequently required hospitalization. No study investigated the biological process to explain how hyperglycemic state worsened the clinical manifestations of Chikungunya in diabetic patients.
conclusionAn important association between DM and the severity of CHIK is observed. Prospective and more rigorous controlled studies are required to generate evidence that might y elucidate the causes of this relationship. Given the fast expanding viral infection of Chikungunya in Central and South America, Asia and Africa in recent years in the context of exponential increase in diabetes globally, the issue deserves global attention.
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