Evidence map›Paper›PMID 29686686›Full record

ArticleFrontiers in immunology2018

Autoimmune Lymphoproliferative Syndrome-FAS Patients Have an Abnormal Regulatory T Cell (Treg) Phenotype but Display Normal Natural Treg-Suppressive Function on T Cell Proliferation.

Fabienne Mazerolles, Marie-Claude Stolzenberg, Olivier Pelle, Capucine Picard, Benedicte Neven, Alain Fischer, Aude Magerus-Chatinet, Frederic Rieux-Laucat

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Genetic Diagnosis Guides Treatment of Autoimmune Enteropathy.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Article
  4. Frontiers in immunology · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Fabienne MazerollesINSERM UMR1163, Laboratory of Immunogenetics of Paediatric Autoimmunity, Paris, France.
Marie-Claude StolzenbergINSERM UMR1163, Laboratory of Immunogenetics of Paediatric Autoimmunity, Paris, France.
Olivier PelleINSERM UMR1163, Laboratory of Immunogenetics of Paediatric Autoimmunity, Paris, France.
Capucine PicardParis Descartes-Sorbonne Paris Cité University, Imagine Institute Paris, Paris, France.
Benedicte NevenINSERM UMR1163, Laboratory of Immunogenetics of Paediatric Autoimmunity, Paris, France.
Alain FischerParis Descartes-Sorbonne Paris Cité University, Imagine Institute Paris, Paris, France.
Aude Magerus-ChatinetINSERM UMR1163, Laboratory of Immunogenetics of Paediatric Autoimmunity, Paris, France.
Frederic Rieux-LaucatINSERM UMR1163, Laboratory of Immunogenetics of Paediatric Autoimmunity, Paris, France.
Inserm · FRInstitut des Maladies Génétiques Imagine · FRCollège de France · FRHôpital Necker-Enfants Malades · FRSorbonne Paris Cité · FR

Funding

European Research Council 249816
6 · The paper itself

Abstract

Objective: Autoimmune lymphoproliferative syndrome (ALPS) with FAS mutation (ALPS-FAS) is a nonmalignant, noninfectious, lymphoproliferative disease with autoimmunity. Given the central role of natural regulatory T cells (nTregs) in the control of lymphoproliferation and autoimmunity, we assessed nTreg-suppressive function in 16 patients with ALPS-FAS. Results: The proportion of CD25 Conclusion: An abnormal Treg phenotype is observed in circulating lymphocytes of ALPS patients. However, these Tregs displayed a normal suppressive function on T effector proliferation

Indexed as

AdolescentAdultAutoimmune Lymphoproliferative SyndromeAutoimmunityBiomarkersChildChild, PreschoolDendritic Cellsfas ReceptorHumansImmunomodulationImmunophenotypingMiddle AgedPhenotypeT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsBiomarkersfas Receptorautoimmune lymphoproliferative syndrome-FAScell proliferationhumanregulatory T cellsuppression assay

Identifiers

PMID29686686
PMCPMC5900038
OpenAlexW2796994512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.