Evidence map›Paper›PMID 29686610›Full record

ArticleFrontiers in human neuroscience2018

Both Reaction Time and Accuracy Measures of Intraindividual Variability Predict Cognitive Performance in Alzheimer's Disease.

Björn U Christ, Marc I Combrinck, Kevin G F Thomas

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Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  12. Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer's disease.Journal of the International Neuropsychological Society : JINS · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Björn U ChristApplied Cognitive Science and Experimental Neuropsychology Team Laboratory, Department of Psychology, University of Cape Town, Cape Town, South Africa.
Marc I CombrinckDivision of Geriatric Medicine, Groote Schuur Hospital, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Kevin G F ThomasApplied Cognitive Science and Experimental Neuropsychology Team Laboratory, Department of Psychology, University of Cape Town, Cape Town, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dementia researchers around the world prioritize the urgent need for sensitive measurement tools that can detect cognitive and functional change at the earliest stages of Alzheimer's disease (AD). Sensitive indicators of underlying neural pathology assist in the early detection of cognitive change and are thus important for the evaluation of early-intervention clinical trials. One method that may be particularly well-suited to help achieve this goal involves the quantification of intraindividual variability (IIV) in cognitive performance. The current study aimed to directly compare two methods of estimating IIV (fluctuations in accuracy-based scores vs. those in latency-based scores) to predict cognitive performance in AD. Specifically, we directly compared the relative sensitivity of reaction time (RT)-and accuracy-based estimates of IIV to cognitive compromise. The novelty of the present study, however, centered on the patients we tested [a group of patients with Alzheimer's disease (AD)] and the outcome measures we used (a measure of general cognitive function and a measure of episodic memory function). Hence, we compared intraindividual standard deviations (iSDs) from two RT tasks and three accuracy-based memory tasks in patients with possible or probable Alzheimer's dementia (

Indexed as

accuracyAlzheimer's diseasecognitionepisodic memoryintraindividual variabilityreaction time

Identifiers

PMID29686610
PMCPMC5900796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.