ArticleMediators of inflammation2018
Notch1 Signaling Regulates the Th17/Treg Immune Imbalance in Patients with Psoriasis Vulgaris.
Article in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The trial behind it
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Molecular Signature and miRNA Pattern of CD4 + T Lymphocytes in Plaque Psoriasis.Clinical reviews in allergy & immunology · 2026Review
- The Impact of Metabolic Syndrome on Immune Regulation (IL-17, IL-23, and FOXP3+), Psoriasis Severity, Flare Frequency, and Quality of Life in Psoriasis Patients: A Cross-Sectional Study.International journal of inflammation · 2025Article
- USP18-mediated protein stabilization of NOTCH1 is associated with altered Th17/Treg cell ratios and B cell-mediated autoantibody secretion in Sjögren syndrome.Immunologic research · 2024Article
- Altered memory CCR6EBioMedicine · 2024Article
- Low-dose Interleukin-2 For Psoriasis Therapy Based on the Regulation of Th17/Treg Cell Balance in Peripheral Blood.Inflammation · 2023Article
- LY294002 ameliorates psoriatic skin inflammation in mice via blocking the Notch1/Hes1-PTEN/AKT/IL-17A feedback loop.Clinical and experimental immunology · 2023Article
- Article
- Signaling pathways in rheumatoid arthritis: implications for targeted therapy.Signal transduction and targeted therapy · 2023Review
- The optimal use of tildrakizumab in the elderly via improvement of Treg function and its preventive effect of psoriatic arthritis.Frontiers in immunology · 2023Article
- The roles of T cells in psoriasis.Frontiers in immunology · 2023Review
- AIM2 and Psoriasis.Frontiers in immunology · 2023Review
- Molecular treatment trajectories within psoriatic T lymphocytes: a mini review.Frontiers in immunology · 2023Review
- Notch1/Hes1‑PTEN/AKT/IL‑17A feedback loop regulates Th17 cell differentiation in mouse psoriasis‑like skin inflammation.Molecular medicine reports · 2022Article
- Annoying Psoriasis and Atopic Dermatitis: A Narrative Review.International journal of molecular sciences · 2022Review
- A narrative review of the role of the Notch signaling pathway in rheumatoid arthritis.Annals of translational medicine · 2022Review
- The Genetic Variants of NOTCH3 (6746T>C) and PSMA6 (-8C>G) as Possible Risk Factors of Psoriasis Development.Life (Basel, Switzerland) · 2021Article
- Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients.Frontiers in cell and developmental biology · 2021Article
- The Role of Helper T Cells in Psoriasis.Frontiers in immunology · 2021Review
- Antigen-Specific Regulatory T Cell Therapy in Autoimmune Diseases and Transplantation.Frontiers in immunology · 2021Review
- SPRC Suppresses Experimental Periodontitis by Modulating Th17/Treg Imbalance.Frontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the regulating effect of Notch1 signaling on Th17/Treg immune imbalance in psoriasis vulgaris (PV). MATERIALS AND
methodsNotch1, Hes-1, ROR
resultsPV patients presented distinct Th17/Treg immune imbalance and highly expressed Notch1 and Hes-1 mRNA levels, which were positively correlated with psoriasis area and severity index (PASI) and the ratios of Th17/Treg and ROR
conclusionNotch1 signaling may contribute to the pathogenesis of PV by regulating Th17/Treg immune imbalance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.