ArticleScientific reports2018
Geometric constraints of endothelial cell migration on electrospun fibres.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
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- Fabrication and characterization of small-caliber nanofibrous vascular scaffolds with sustained release of endothelial cell derivatives and heparin.Frontiers in bioengineering and biotechnology · 2026Article
- The Influence of Textile Structure Characteristics on the Performance of Artificial Blood Vessels.Polymers · 2023Review
- How the Nonwoven Polymer Volume Microstructure Is Transformed under Tension in an Aqueous Environment.Polymers · 2022Article
- Structural Aspects of Electrospun Scaffolds Intended for Prosthetics of Blood Vessels.Polymers · 2022Review
- A critical review of fibrous polyurethane-based vascular tissue engineering scaffolds.Journal of biological engineering · 2022Review
- Accelerated Endothelialization of Nanofibrous Scaffolds for Biomimetic Cardiovascular Implants.Materials (Basel, Switzerland) · 2022Article
- Pericytes' Circadian Clock Affects Endothelial Cells' Synchronization and Angiogenesis in a 3D Tissue Engineered Scaffold.Frontiers in pharmacology · 2022Article
- PEOT/PBT Polymeric Pastes to Fabricate Additive Manufactured Scaffolds for Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021Article
- Strategies to Improve Nanofibrous Scaffolds for Vascular Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2020Review
- Electrospun Fibre Webs Templated Synthesis of Mineral Scaffolds Based on Calcium Phosphates and Barium Titanate.Nanomaterials (Basel, Switzerland) · 2020Article
- General Study and Gene Expression Profiling of Endotheliocytes Cultivated on Electrospun Materials.Materials (Basel, Switzerland) · 2019Article
- Altered processing enhances the efficacy of small-diameter silk fibroin vascular grafts.Scientific reports · 2019Article
- Bioactive factors for cartilage repair and regeneration: Improving delivery, retention, and activity.Acta biomaterialia · 2019Review
- Cellular Response to Surface Morphology: Electrospinning and Computational Modeling.Frontiers in bioengineering and biotechnology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomaterial scaffolds that can form a template for tissue growth and repair forms the basis of many tissue engineering paradigms. Cell migration and colonisation is an important, and often overlooked, first step. In this study, fibrous guidance structures were produced via electrospinning and the effect of physical features such as fibre diameter (ranging from 500 nm to 10 μm) on endothelial cell migration was assessed. Using a modified wound healing assay, fibre diameter was found to have a significant effect on the rate of wound closure and the peak migration velocity of the cells with scaffold diameter shown to influence both morphology and alignment of the migrating cells. The expression, phosphorylation and distribution of focal adhesion kinase (FAK) was disrupted on the different scaffolds with small-diameter scaffolds exhibiting increased FAK phosphorylation with the kinase present in the cytosol whereas on large-diameter scaffolds FAK was largely restricted to focal adhesions at the cell periphery. This study demonstrates that electrospun scaffolds can be used to model cell migration on fibrous substrates, and particularly for the studying effects of physical features of the substrate, and that FAK is a key mediator of cell-scaffold interactions on migrating cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.