Evidence map›Paper›PMID 29686427›Full record

ArticleNature communications2018

A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation.

Ewoud B Compeer, Felix Kraus, Manuela Ecker, Gregory Redpath, Mayan Amiezer, Nils Rother, Philip R Nicovich, Natasha Kapoor-Kaushik, Qiji Deng, Guerric P B Samson and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Endocytosis in cancer and cancer therapy.Nature reviews. Cancer · 2023
    Review
  12. Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Deliver on Time or Pay the Fine: Scheduling in Membrane Trafficking.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Ewoud B CompeerEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0002-8945-0010
Felix KrausEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0002-3757-541X
Manuela EckerEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Gregory RedpathEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Mayan AmiezerEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Nils RotherEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Philip R NicovichEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Natasha Kapoor-KaushikEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Qiji DengEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Guerric P B SamsonBiotechnology Institute Thurgau at the University of Konstanz, 8280, Kreuzlingen, Switzerland.
Zhengmin YangEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Jieqiong LouEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Michael CarnellBiomedical Imaging Facility, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Haig VartoukianEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Katharina GausEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia.
Jérémie RossyEMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, High St Gate 9, Sydney, NSW, 2052, Australia. jeremie.rossy@bitg.ch.ORCID http://orcid.org/0000-0002-5128-5283
UNSW Sydney · AUBiotechnology Institute Thurgau · CHEMBL Australia · AUGarvan Institute of Medical Research · AURadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endocytosis of surface receptors and their polarized recycling back to the plasma membrane are central to many cellular processes, such as cell migration, cytokinesis, basolateral polarity of epithelial cells and T cell activation. Little is known about the mechanisms that control the organization of recycling endosomes and how they connect to receptor endocytosis. Here, we follow the endocytic journey of the T cell receptor (TCR), from internalization at the plasma membrane to recycling back to the immunological synapse. We show that TCR triggering leads to its rapid uptake through a clathrin-independent pathway. Immediately after internalization, TCR is incorporated into a mobile and long-lived endocytic network demarked by the membrane-organizing proteins flotillins. Although flotillins are not required for TCR internalization, they are necessary for its recycling to the immunological synapse. We further show that flotillins are essential for T cell activation, supporting TCR nanoscale organization and signaling.

Indexed as

AnimalsCell Line, TumorCell MembraneEndocytosisHumansImmunological SynapsesLymphocyte ActivationMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutPrimary Cell CultureReceptors, Antigen, T-CellSignal TransductionT-LymphocytesflotillinsMembrane ProteinsReceptors, Antigen, T-Cell

Identifiers

PMID29686427
PMCPMC5913236
OpenAlexW2800448164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.