SynthesisScientific reports2018
Influence of age on histologic outcome of cervical intraepithelial neoplasia during observational management: results from large cohort, systematic review, meta-analysis.
Synthesis in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Rapid Systematic Review-Informed Multidisciplinary Expert Consensus on the Management of HPV-Positive Women with Low-Grade Cervical Lesions and the Role of aMedicina (Kaunas, Lithuania) · 2026Pooled it
- 2023 Canadian Colposcopy Guideline: A Risk-Based Approach to Management and Surveillance of Cervical Dysplasia.Current oncology (Toronto, Ont.) · 2023Guideline
- Phase I and II randomized clinical trial of an oral therapeutic vaccine targeting human papillomavirus for treatment of cervical intraepithelial neoplasia 2 and 3.JNCI cancer spectrum · 2023Trial
- Value of a catch-up HPV test in women aged 65 and above: A Danish population-based nonrandomized intervention study.PLoS medicine · 2023Trial
- Clinical Outcomes of a Multi-IngredientCancers · 2026Article
- Article
- Regression of high-grade squamous intraepithelial lesions in women aged 30 years or younger: a retrospective cohort study.Journal of cancer research and clinical oncology · 2026Article
- Young women with (pre)malignant cervical disease in northern Netherlands: what characterises them - A population-based cohort study.BMC women's health · 2026Article
- Registry Study of the Working Group on Cervical Pathology and Colposcopy (AGCPC) on the Diagnostic Algorithm for the New Cervical Cancer Screening - Persistent HPV Infections and Squamous Cell Lesions: Evaluation of over 10000 Patients.Geburtshilfe und Frauenheilkunde · 2026Article
- Cervical Dysplasia Diagnosed in Pregnancy - A Pre- and Postpartum Analysis.Geburtshilfe und Frauenheilkunde · 2026Article
- Changes of Swede Score in Low-Grade Cervical Precancerous Lesions After Administration ofInternational journal of women's health · 2026Article
- Risk of CIN2+ in women aged >60 years with abnormal cervical cancer screening: a multicenter retrospective cohort study from the Thai Gynecologic Cancer Society research group.Journal of gynecologic oncology · 2025Article
- Retrospective Analysis of Human Papillomavirus Genotyping and Cytology (Pap Smears) in Cervical Cancer Screening: An Institutional Experience in the State of Oregon, USA.Diagnostics (Basel, Switzerland) · 2025Article
- Clinical characteristics and treatment outcomes of cervical high-grade squamous intraepithelial lesions in women under 25 years: a retrospective cohort study.Frontiers in oncology · 2025Article
- Role of theFrontiers in oncology · 2025Article
- Histologically confirmed high-grade cervical intraepithelial neoplasia successfully treated with topical Paiteling: a two-case report.Frontiers in medicine · 2025Article
- Immediate risk of cervical intraepithelial neoplasia and diagnostic value of colposcopy among cytology-negative women with oncogenic HPV: a retrospective study.BMC women's health · 2024Article
- PCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women: a prospective cohort study.BMC medicine · 2024Article
- Cost-utility and budget impact analyses of cervical cancer screening using self-collected samples for HPV DNA testing in Thailand.BMC public health · 2023Article
- Registry Study of the Working Group on Cervical Pathology and Colposcopy (AGCPC) on the Diagnostic Algorithm for the New Cervical Cancer Screening - Initial Data.Geburtshilfe und Frauenheilkunde · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim of this study was to investigate the histologic outcome of cervical intraepithelial neoplasia (CIN) during observational management. Consecutive women with histologically verified CIN and observational management were included. Histologic findings of initial and follow-up visits were collected and persistence, progression and regression rates at end of observational period were assessed. Uni- and multivariate analyses were performed. A systematic review of the literature and meta-analysis was performed. In 783 women CIN I, II, and III was diagnosed by colposcopically guided biopsy in 42.5%, 26.6% and 30.9%, respectively. Younger patients had higher rates of regression (p < 0.001) and complete remission (< 0.001) and lower rates of progression (p = 0.003). Among women aged < 25, 25 < 30, 30 < 35, 35 < 40 years, and > 40 years, regression rates were 44.7%, 33.7%, 30.9%, 27.3%, and 24.9%, respectively. Pooled analysis of published data showed similar results. Multivariable analysis showed that with each five years of age, the odds for regression reduced by 21% (p < 0.001) independently of CIN grade (p < 0.001), and presence of HPV high-risk infection (p < 0.001). Patient's age has a considerable influence on the natural history of CIN - independent of CIN grade and HPV high-risk infection. Observational management should be considered for selected young patients with CIN.
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