Evidence map›Paper›PMID 29686379›Full record

ArticleInternational journal of obesity (2005)2018

Maternal early pregnancy obesity and related pregnancy and pre-pregnancy disorders: associations with child developmental milestones in the prospective PREDO Study.

Polina Girchenko, Soile Tuovinen, Marius Lahti-Pulkkinen, Jari Lahti, Katri Savolainen, Kati Heinonen, Riikka Pyhälä, Rebecca M Reynolds, Esa Hämäläinen, Pia M Villa and 4 more

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In one paragraph

Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 6 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Polina GirchenkoDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Soile TuovinenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Marius Lahti-PulkkinenDepartment of Psychology and Logopedics, University of Helsinki, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Jari LahtiDepartment of Psychology and Logopedics, University of Helsinki, Helsinki Collegium of Advanced Studies University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4310-5297
Katri SavolainenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Kati HeinonenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Riikka PyhäläDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Rebecca M ReynoldsEndocrinology Unit, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Esa HämäläinenHUSLAB and Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland.
Pia M VillaDepartment of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Eero KajantieNational Institute for Health and Welfare, Helsinki and Oulu, Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Anu-Katriina PesonenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Hannele LaivuoriMedical and Clinical Genetics University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Katri RäikkönenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland. katri.raikkonen@helsinki.fi.
University of Helsinki · FIThe Queen's Medical Research Institute · GBHelsinki University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesPrevious studies have linked maternal pre-pregnancy obesity (BMI ≥30 kg/m SUBJECTS/

methodsA total of 2504 mother-child dyads participated in the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study. Data on maternal early pregnancy obesity, pre-pregnancy, and gestational hypertension, pre-eclampsia, type 1 and gestational diabetes were derived from the Finnish Medical Birth Register. At the child's mean age of 42.1 (SD = 8.2) months the mothers completed the Ages and Stages Questionnaire (ASQ) Third edition for developmental milestones.

resultsChildren of obese mothers had 1.81-2.74 (p-values <0.02) higher odds of failing to meet the development that is typical for a child's age (developmental domain score ≤-2SD below the child's age) on the communication, fine and gross motor, problem solving and personal/social skills and children of overweight mothers had 2.14 (p = 0.002) higher odds of failing to meet the development that is typical for the child's age on communication skills. Odds of developmental delay were also higher for children of mothers with pre-eclampsia and gestational diabetes. The associations were robust to covariates and confounders, the effects of overweight/obesity and pre-eclampsia were not driven by the other disorders, and overweight/obesity and hypertensive and diabetic disorders did not show additive effects.

conclusionsMaternal early pregnancy overweight, obesity, and pre-eclampsia are independently associated with neurodevelopmental delay in her offspring. Further studies unraveling the underlying mechanisms are warranted.

Indexed as

AdultChild DevelopmentChild, PreschoolDevelopmental DisabilitiesDiabetes, GestationalFemaleFollow-Up StudiesHumansMaleObesityPre-EclampsiaPregnancyPregnancy Complications

Identifiers

PMID29686379
OpenAlexW2801085362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.