Evidence map›Paper›PMID 29686297›Full record

ArticleNature microbiology2018

Microbiota-accessible carbohydrates suppress Clostridium difficile infection in a murine model.

Andrew J Hryckowian, William Van Treuren, Samuel A Smits, Nicole M Davis, Jackson O Gardner, Donna M Bouley, Justin L Sonnenburg

Abstract read
In one paragraph

Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 257 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Review
  6. [Butyrate alleviatesNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  7. Article
  8. Review
  9. bioRxiv : the preprint server for biology · 2026
    Article
  10. Acidification-dependent suppression ofInfection and immunity · 2026
    Article
  11. Article
  12. Article
  13. Acidification-dependent suppression ofbioRxiv : the preprint server for biology · 2026
    Article
  14. International journal of microbiology · 2026
    Article
  15. Infection strategies ofGut microbes reports · 2026
    Review
  16. Article
  17. Gut microbes · 2025
    Article
  18. Review
  19. The emerging view on the roles of butyrate inInfection and immunity · 2025
    Review
  20. Article

94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrew J HryckowianDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
William Van TreurenDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Samuel A SmitsDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Nicole M DavisDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Jackson O GardnerDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Donna M BouleyDepartment of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Justin L SonnenburgDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. jsonnenburg@stanford.edu.ORCID http://orcid.org/0000-0003-2299-6817
Stanford University · US

Funding

MOLECULAR BASIS OF HOST-PARASITE INTERACTIONT32AI007328 · NIAID · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 1987 to 2026
$11.9M
Impact of Diet on Intestinal Microbiota-Host DynamicsR01DK085025 · NIDDK · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 2010 to 2026
$6.4M
NIAID NIH HHS T32 AI007328NIDDK NIH HHS R01 DK085025
6 · The paper itself

Abstract

Clostridium difficile is an opportunistic diarrhoeal pathogen, and C. difficile infection (CDI) represents a major health care concern, causing an estimated 15,000 deaths per year in the United States alone

Indexed as

AnimalsAnti-Bacterial AgentsClostridioides difficileClostridium InfectionsDietary CarbohydratesDisease Models, AnimalDysbiosisGastrointestinal MicrobiomeHumansInulinMicePlantsTreatment OutcomeAnti-Bacterial AgentsDietary CarbohydratesInulin

Identifiers

PMID29686297
PMCPMC6126909
OpenAlexW2800136432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.