Evidence map›Paper›PMID 29686294›Full record

ArticleScientific reports2018

Development of new method to enrich human iPSC-derived renal progenitors using cell surface markers.

Azusa Hoshina, Tatsuya Kawamoto, Shin-Ichi Sueta, Shin-Ichi Mae, Toshikazu Araoka, Hiromi Tanaka, Yasunori Sato, Yukiko Yamagishi, Kenji Osafune

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. iPSC technology-based regenerative medicine for kidney diseases.Clinical and experimental nephrology · 2021
    Review
  10. Article
  11. Stem cells and lung regeneration.American journal of physiology. Cell physiology · 2020
    Review
  12. Kidney organoids in translational medicine: Disease modeling and regenerative medicine.Developmental dynamics : an official publication of the American Association of Anatomists · 2020
    Review
  13. Review
  14. Application of iPSC to Modelling of Respiratory Diseases.Advances in experimental medicine and biology · 2020
    Review
  15. Stem Cell Therapies in Kidney Diseases: Progress and Challenges.International journal of molecular sciences · 2019
    Review
  16. Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Azusa HoshinaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Tatsuya KawamotoDrug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan. tatsuya.kawamoto@astellas.com.
Shin-Ichi SuetaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Shin-Ichi MaeCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Toshikazu AraokaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Hiromi TanakaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Yasunori SatoDepartment of Global Clinical Research, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.
Yukiko YamagishiDrug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan.ORCID 0000-0002-2613-2744
Kenji OsafuneCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. osafu@cira.kyoto-u.ac.jp.ORCID 0000-0001-7238-2763
Kyoto University · JPAstellas Pharma (Japan) · JPChiba University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell therapy using renal progenitors differentiated from human embryonic stem cells (hESCs) or induced pluripotent stem cells (hiPSCs) has the potential to significantly reduce the number of patients receiving dialysis therapy. However, the differentiation cultures may contain undifferentiated or undesired cell types that cause unwanted side effects, such as neoplastic formation, when transplanted into a body. Moreover, the hESCs/iPSCs are often genetically modified in order to isolate the derived renal progenitors, hampering clinical applications. To establish an isolation method for renal progenitors induced from hESCs/iPSCs without genetic modifications, we screened antibodies against cell surface markers. We identified the combination of four markers, CD9

Indexed as

Acute Kidney InjuryAnimalsBiomarkersCell- and Tissue-Based TherapyCell DifferentiationCells, CulturedCell SeparationEmbryonic Stem CellsHumansInduced Pluripotent Stem CellsMiceStem Cell TransplantationBiomarkers

Identifiers

PMID29686294
PMCPMC5913312
OpenAlexW2802080432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.