ArticleNature communications2018
Identity prediction errors in the human midbrain update reward-identity expectations in the orbitofrontal cortex.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 100 citations in OpenAlex.
- Interactions between human orbitofrontal cortex and hippocampus support model-based inference.PLoS biology · 2020Trial
- Methamphetamine potentiates the use of outcome-specific associations via a hypothalamic-dopamine circuit.Neuron · 2026Article
- Prediction error correlates in the striosome-dopamine circuit emerge from information gain.Nature communications · 2026Article
- Mesocorticostriatal Reinforcement Learning of State Representation and Value with Implications for the Mechanisms of Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Insights into effortful adaptation during speech perception: The role of dopamine, norepinephrine, and prediction error.Cognitive, affective & behavioral neuroscience · 2026Review
- Dopaminergic responses to identity prediction errors depend differently on the orbitofrontal cortex and hippocampus.Behavioral neuroscience · 2026Article
- An Integrative Appraisal Model of Epistemic Curiosity.Affective science · 2025Review
- Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior.bioRxiv : the preprint server for biology · 2025Article
- The curious case of dopaminergic prediction errors and learning associative information beyond value.Nature reviews. Neuroscience · 2025Review
- Complementary roles of serotonin and dopamine in model-based learning.Current opinion in behavioral sciences · 2025Article
- Modality-specific and modality-general representations of subjective value in frontal cortex.Communications biology · 2024Article
- Distributed midbrain responses signal the content of positive identity prediction errors.Current biology : CB · 2024Article
- Dopamine Release in the Nucleus Accumbens Core Encodes the General Excitatory Components of Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Encoding of Predictive Associations in Human Prefrontal and Medial Temporal Neurons During Pavlovian Appetitive Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories.Nature neuroscience · 2024Article
- Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks.Nature communications · 2024Article
- The cognitive (lateral) hypothalamus.Trends in cognitive sciences · 2024Review
- Neural substrates of parallel devaluation-sensitive and devaluation-insensitive Pavlovian learning in humans.Nature communications · 2023Article
- Long-term, multi-event surprise correlates with enhanced autobiographical memory.Nature human behaviour · 2023Article
- Lateral orbitofrontal cortex integrates predictive information across multiple cues to guide behavior.Current biology : CB · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
There is general consensus that dopaminergic midbrain neurons signal reward prediction errors, computed as the difference between expected and received reward value. However, recent work in rodents shows that these neurons also respond to errors related to inferred value and sensory features, indicating an expanded role for dopamine beyond learning cached values. Here we utilize a transreinforcer reversal learning task and functional magnetic resonance imaging (fMRI) to test whether prediction error signals in the human midbrain are evoked when the expected identity of an appetitive food odor reward is violated, while leaving value matched. We found that midbrain fMRI responses to identity and value errors are correlated, suggesting a common neural origin for these error signals. Moreover, changes in reward-identity expectations, encoded in the orbitofrontal cortex (OFC), are directly related to midbrain activity, demonstrating that identity-based error signals in the midbrain support the formation of outcome identity expectations in OFC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.