Evidence map›Paper›PMID 29686224›Full record

ArticleInternational journal of oral science2018

Activation of β-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects.

Tianqian Hui, Yachuan Zhou, Tingyu Wang, Jun Li, Shanxing Zhang, Lifan Liao, Jianhong Gu, Ling Ye, Lan Zhao, Di Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of oral science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 43 citations in OpenAlex.

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  17. Wnt signalling in the articular cartilage: A matter of balance.International journal of experimental pathology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Tianqian HuiDepartment of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, China.
Yachuan ZhouDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, USA.
Tingyu WangDepartment of Pharmacy, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Jun LiDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, USA.
Shanxing ZhangDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, USA.
Lifan LiaoDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, USA.
Jianhong GuDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, USA.
Ling YeState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Lan ZhaoDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, USA.
Di ChenDepartment of Orthopaedic Surgery, Rush University Medical Center, Chicago, USA. di_chen@rush.edu.
Rush University Medical Center · USShanghai Ninth People's Hospital · CNShenzhen University · CNState Key Laboratory of Oral Diseases

Funding

The Mechanism through which TGF-Beta Maintains Chondrocytes in Proliferating StagR01AR054465 · NIAMS · UNIVERSITY OF ROCHESTER · PI CHEN, DI · 2007 to 2018
$2.7M
The Role of MicroRNA in Osteoarthritis: Alzheimer's Administrative SupplementR01AR070222 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI HUANG, JIAN, ZHAO, LAN · 2017 to 2022
$2.1M
NIAMS NIH HHS R01 AR054465NIAMS NIH HHS R01 AR070222
6 · The paper itself

Abstract

β-Catenin plays a critical role in cartilage formation and development. To further understand the role of β-catenin in osteoarthritis (OA) development in temporomandibular joint (TMJ), we have generated β-catenin conditional activation mice (β-cat(ex3)

Indexed as

AggrecansAnimalsApoptosisbeta CateninCartilage, ArticularCell DifferentiationCell ProliferationCells, CulturedDisease Models, AnimalIn Situ Nick-End LabelingMiceOsteoarthritisPhenotypeSignal TransductionSurface PropertiesTemporomandibular JointAggrecansbeta Catenin

Identifiers

PMID29686224
PMCPMC5966811
OpenAlexW2804886395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.