ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Circular RNA hsa-circ-0012129 Promotes Cell Proliferation and Invasion in 30 Cases of Human Glioma and Human Glioma Cell Lines U373, A172, and SHG44, by Targeting MicroRNA-661 (miR-661).
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- CircRNAs as potential biomarkers for the clinicopathology and prognosis of glioma patients: a meta-analysis.BMC cancer · 2020Pooled it
- Analyzing the expression of hsa-miR-661 in peripheral blood mononuclear cells of patients with primary Sjögren's syndrome and its clinical significance.Clinical rheumatology · 2026Article
- Computational Screening to Predict MicroRNA Targets in the Flavivirus 3' UTR Genome: An Approach for Antiviral Development.International journal of molecular sciences · 2024Article
- Roles of circular RNAs in regulating the development of glioma.Journal of cancer research and clinical oncology · 2023Review
- Role of Circular RNA in Brain Tumor Development.Cells · 2022Review
- CircRFX3 contributes to glioma progression through the circRFX3-miR-1179/miR-1229-VASP axis.Cancer cell international · 2021Article
- hsa_circ_0058357 acts as a ceRNA to promote non‑small cell lung cancer progression via the hsa‑miR‑24‑3p/AVL9 axis.Molecular medicine reports · 2021Article
- CircWEE1/miR-138 axis promotes the malignant progression of glioma by regulating SIRT1.Translational cancer research · 2021Article
- Review on circular RNAs and new insights into their roles in cancer.Computational and structural biotechnology journal · 2021Review
- Advances in circular RNAs and their role in glioma (Review).International journal of oncology · 2020Article
- circKIF4A promotes tumorogenesis of glioma by targeting miR-139-3p to activate Wnt5a signaling.Molecular medicine (Cambridge, Mass.) · 2020Article
- Ectopic expression of CYP24A1 circular RNA hsa_circ_0060927 in uterine leiomyomas.Journal of clinical laboratory analysis · 2020Article
- Role of circular RNAs in brain development and CNS diseases.Progress in neurobiology · 2020Review
- Functions and clinical significance of circular RNAs in glioma.Molecular cancer · 2020Review
- Lcn2-derived Circular RNA (hsa_circ_0088732) Inhibits Cell Apoptosis and Promotes EMT in Glioma via the miR-661/RAB3D Axis.Frontiers in oncology · 2020Article
- Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells.Medical science monitor : international medical journal of experimental and clinical research · 2019Review
- Circ-ZNF264 Promotes the Growth of Glioma Cells by Upregulating the Expression of miR-4493 Target Gene Apelin.Journal of molecular neuroscience : MN · 2019Article
- Putative biomarkers of malignant transformation of sinonasal inverted papilloma into squamous cell carcinoma.The Journal of international medical research · 2019Article
- Signature of circular RNAs in peripheral blood mononuclear cells from patients with active tuberculosis.Journal of cellular and molecular medicine · 2019Article
- Circular RNAs and human glioma.Cancer biology & medicine · 2019Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Circular RNA (circRNA) is a stable non-coding RNA without 5'-3' polarity and without a poly-A tail, that contains response elements for microRNAs (miRNAs) such as miR-661. There have previously been few reported studies on the role of circRNAs in glioma. The aim of this study was to investigate the effects of the expression of the circRNA, hsa-circ-0012129, and miR-661 in human glioma tissue and human glioma cell lines. MATERIAL AND METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of hsa-circ-0012129 and miR-661 in glioma tissues from 31 patients (WHO grades I-IV), compared with adjacent normal tissue, and in human glioma cell lines, U373, A172, and SHG44, compared with the normal human astrocyte cell line, NHA. The MTT assay, colony formation assay, transwell and wound scratch assays were performed to analyze and compare cell viability, cell migration, and invasion. RESULTS Expression of hsa-circ-0012129 was significantly increased in glioma tissues and cell lines; hsa-circ-0012129 knockdown significantly suppressed the proliferation, migration, and invasion abilities of U373 and SHG44 cells. A dual-luciferase reporter assay showed that hsa-circ-0012129 contained the complementary binding region with miR-661 and that hsa-circ-0012129 expression negatively regulated miR-661. Rescue experiments showed that miR-661 could reverse the effects of hsa-circ-0012129 on cell viability, cell migration and invasion of glioma cells in vitro. CONCLUSIONS The findings of this study indicated that, in human glioma cells, the circRNA, hsa-circ-0012129 might act as a natural miR-661 sponge, and that miR-661 could have suppressive effects on the expression of circ-0012129.
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