Evidence map›Paper›PMID 29686103›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Abscisic acid-induced degradation of

Zixing Li, Yohei Takahashi, Alexander Scavo, Benjamin Brandt, Desiree Nguyen, Philippe Rieu, Julian I Schroeder

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. An ABA-ROP toggle switch orchestrates xylem differentiation and cell wall patterning.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. ABA-activated low-nanomolar CaNature plants · 2025
    Article
  6. Carotenoid Accumulation in thePlants (Basel, Switzerland) · 2024
    Article
  7. TheInternational journal of molecular sciences · 2024
    Article
  8. SCAB1 coordinates sequential CaScience China. Life sciences · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Stomatal COScience advances · 2022
    Article
  16. Article
  17. The aquaporin gene PvXIP1;2 conferring drought resistance identified by GWAS at seedling stage in common bean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022
    Article
  18. eIF4E1 RegulatesFrontiers in plant science · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zixing LiDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA 92093 zil050@ucsd.edu jischroeder@ucsd.edu.
Yohei TakahashiDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA 92093.
Alexander ScavoDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA 92093.
Benjamin BrandtDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA 92093.
Desiree NguyenDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA 92093.
Philippe RieuDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA 92093.
Julian I SchroederDivision of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA 92093 zil050@ucsd.edu jischroeder@ucsd.edu.
University of California, San Diego · US

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
STRESS HORMONE SIGNAL TRANSDUCTION IN ARABIDOPSISR01GM060396 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHROEDER, JULIAN I · 2000 to 2023
$7.4M
NIEHS NIH HHS P42 ES010337NIGMS NIH HHS R01 GM060396
6 · The paper itself

Abstract

Abscisic acid (ABA) plays essential roles in plant development and responses to environmental stress. ABA induces subcellular translocation and degradation of the guanine nucleotide exchange factor RopGEF1, thus facilitating ABA core signal transduction. However, the underlying mechanisms for ABA-triggered RopGEF1 trafficking/degradation remain unknown. Studies have revealed that RopGEFs associate with receptor-like kinases to convey developmental signals to small ROP GTPases. However, how the activities of RopGEFs are modulated is not well understood. Type 2C protein phosphatases stabilize the RopGEF1 protein, indicating that phosphorylation may trigger RopGEF1 trafficking and degradation. We have screened inhibitors followed by several protein kinase mutants and find that quadruple-mutant plants in the

Indexed as

Abscisic AcidArabidopsisArabidopsis ProteinsCalcium-Calmodulin-Dependent Protein KinasesGene Expression Regulation, PlantGuanine Nucleotide Exchange FactorsPhosphorylationPlant Growth RegulatorsPlant RootsProtein TransportProteolysisSignal TransductionAbscisic AcidArabidopsis ProteinsCalcium-Calmodulin-Dependent Protein KinasesCPK4 protein, ArabidopsisGuanine Nucleotide Exchange FactorsPlant Growth RegulatorsRopGEF1 protein, ArabidopsisABAabiotic stressCPKprotein phosphorylation and degradationRopGEF

Identifiers

PMID29686103
PMCPMC5948973
OpenAlexW2799331809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.