ArticleProceedings of the National Academy of Sciences of the United States of America2018
Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 109 citations in OpenAlex.
- Selective advantages, selective mismatches, chronic inflammation, obesity, and type 2 diabetes: a new hypothesis to explain the effects of natural selection on genetic variation at the ectodysplasin A receptor locus.BMJ open diabetes research & care · 2026Review
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- The Meaning of Mangabey Molars (And Premolars).Evolutionary anthropology · 2026Review
- Comparative analysis of milk and brain fatty acids reveals human-specific signatures in brain development.Communications biology · 2026Article
- Defining breast epithelial cell types in the single-cell era.Developmental cell · 2025Review
- Human population dynamics in Upper Paleolithic Europe inferred from fossil dental phenotypes.Science advances · 2024Article
- Genomic imputation of ancient Asian populations contrasts local adaptation in pre- and post-agricultural Japan.iScience · 2024Article
- Sex-biased gene regulation varies across human populations as a result of adaptive evolution.American journal of biological anthropology · 2024Article
- The STROMICS genome study: deep whole-genome sequencing and analysis of 10K Chinese patients with ischemic stroke reveal complex genetic and phenotypic interplay.Cell discovery · 2023Article
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- Genetic/Protein Association of Atopic Dermatitis and Tooth Agenesis.International journal of molecular sciences · 2023Review
- Beringia and the peopling of the Western Hemisphere.Proceedings. Biological sciences · 2023Review
- Teeth, prenatal growth rates, and the evolution of human-like pregnancy in laterProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion.Acta paediatrica (Oslo, Norway : 1992) · 2022Review
- Novel alleles gained during the Beringian isolation period.Scientific reports · 2022Article
- Article
- RNA Sequencing Analysis Reveals Divergent Adaptive Response to Hypo- and Hyper-Salinity in Greater Amberjack (Animals : an open access journal from MDPI · 2022Article
- Evidence of Selection in the Ectodysplasin Pathway among Endangered Aquatic Mammals.Integrative organismal biology (Oxford, England) · 2022Article
- Prioritising positively selected variants in whole-genome sequencing data using FineMAV.BMC bioinformatics · 2021Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because of the ubiquitous adaptability of our material culture, some human populations have occupied extreme environments that intensified selection on existing genomic variation. By 32,000 years ago, people were living in Arctic Beringia, and during the Last Glacial Maximum (LGM; 28,000-18,000 y ago), they likely persisted in the Beringian refugium. Such high latitudes provide only very low levels of UV radiation, and can thereby lead to dangerously low levels of biosynthesized vitamin D. The physiological effects of vitamin D deficiency range from reduced dietary absorption of calcium to a compromised immune system and modified adipose tissue function. The ectodysplasin A receptor (
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