Evidence map›Paper›PMID 29686090›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Complementary charge-based interaction between the ribosomal-stalk protein L7/12 and IF2 is the key to rapid subunit association.

Xueliang Ge, Chandra Sekhar Mandava, Christoffer Lind, Johan Åqvist, Suparna Sanyal

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. AJournal of bacteriology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Extraribosomal Functions of Bacterial Ribosomal Proteins-An Update, 2023.International journal of molecular sciences · 2024
    Review
  8. Early divergence of translation initiation and elongation factors.Protein science : a publication of the Protein Society · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Tetrapeptide Ac-HAEE-NHInternational journal of molecular sciences · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xueliang GeDepartment of Cell and Molecular Biology, Uppsala University, 75124 Uppsala, Sweden.ORCID 0000-0001-7954-3195
Chandra Sekhar MandavaDepartment of Cell and Molecular Biology, Uppsala University, 75124 Uppsala, Sweden.ORCID 0000-0002-3028-3270
Christoffer LindDepartment of Cell and Molecular Biology, Uppsala University, 75124 Uppsala, Sweden.
Johan ÅqvistDepartment of Cell and Molecular Biology, Uppsala University, 75124 Uppsala, Sweden.
Suparna SanyalDepartment of Cell and Molecular Biology, Uppsala University, 75124 Uppsala, Sweden suparna.sanyal@icm.uu.se.ORCID 0000-0002-7124-792X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interaction between the ribosomal-stalk protein L7/12 (L12) and initiation factor 2 (IF2) is essential for rapid subunit association, but the underlying mechanism is unknown. Here, we have characterized the L12-IF2 interaction on

Indexed as

Molecular Docking SimulationMolecular Dynamics SimulationPeptide Chain Initiation, TranslationalAmino Acid MotifsEscherichia coliEscherichia coli ProteinsMutationProkaryotic Initiation Factor-2Ribosomal ProteinsEscherichia coli ProteinsProkaryotic Initiation Factor-2Ribosomal ProteinsrplL protein, E coliprotein–protein interactionprotein synthesisribosomal protein L7/12ribosometranslation initiation

Identifiers

PMID29686090
PMCPMC5939111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.