ArticleProceedings of the National Academy of Sciences of the United States of America2018
Recurrent structural variation, clustered sites of selection, and disease risk for the complement factor H (
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed.
- Extended haplotypes at the complement factor H gene locus are associated with liver transplant rejection.Hepatology communications · 2026Article
- Loss of CFHR5 function reduces the risk for age-related macular degeneration.Nature communications · 2025Article
- Friend or foe: assessing the value of animal models for facilitating clinical breakthroughs in complement research.The Journal of clinical investigation · 2025Review
- Rare predicted loss-of-function and damaging missense variants in CFHR5 associate with protection from age-related macular degeneration.American journal of human genetics · 2025Article
- Factor H-related 2 levels dictate FHR dimer composition.Scientific reports · 2025Article
- Developing an insert to protect large DNA molecules during cell lysis.BioTechniques · 2025Article
- A case of non-lupus full-house nephropathy diagnosed by kidney biopsy but observed IgA nephropathy on second biopsy.CEN case reports · 2024Article
- The Importance of Copy Number Variant Analysis in Patients with Monogenic Kidney Disease.Kidney international reports · 2024Article
- Article
- Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression.Nature communications · 2024Article
- The human factor H protein family - an update.Frontiers in immunology · 2024Review
- Factor H-related protein 1 in systemic lupus erythematosus.Frontiers in immunology · 2024Article
- Immunological risk and complement genetic evaluations in early onset de novo thrombotic microangiopathy after living donor kidney transplantation: A Japanese multicenter registry.Clinical and experimental nephrology · 2023Article
- CFH-CFHR1 hybrid genes in two cases of atypical hemolytic uremic syndrome.Journal of human genetics · 2023Article
- Concentration of lambda concatemers using a 3D printed device.Electrophoresis · 2023Article
- Structurally divergent and recurrently mutated regions of primate genomes.bioRxiv : the preprint server for biology · 2023Article
- The Factor H protein family: The switchers of the complement alternative pathway.Immunological reviews · 2023Review
- C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration.International journal of retina and vitreous · 2022Review
- An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2022Article
- Rapid divergence of a gamete recognition gene promoted macroevolution of Eutheria.Genome biology · 2022Article
Corrections and comments
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Authors and funding
19 authors.
Stuart CantsilierisDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195.
Bradley J NelsonDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195.
John HuddlestonDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195.
Carl BakerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195.
Lana HarshmanDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195.
Kelsi PenewitDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195.
Katherine M MunsonDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195.
Melanie SorensenDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195.ORCID 0000-0002-1525-9707
AnneMarie E WelchDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195.
Vy DangDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195.
Felix GrassmannInstitute of Human Genetics, University of Regensburg, 93053 Regensburg, Germany.
Andrea J RichardsonCentre for Eye Research Australia, Department of Surgery (Ophthalmology), University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC 3002, Australia.
Robyn H GuymerCentre for Eye Research Australia, Department of Surgery (Ophthalmology), University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC 3002, Australia.
Tina A Graves-LindsayMcDonnell Genome Institute at Washington University, St. Louis, MO 63108.
Richard K WilsonInstitute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43205.
Bernhard H F WeberInstitute of Human Genetics, University of Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-8808-7723
Paul N BairdCentre for Eye Research Australia, Department of Surgery (Ophthalmology), University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC 3002, Australia.
Rando AllikmetsDepartment of Ophthalmology, Columbia University, New York, NY 10027.
Evan E EichlerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195; eee@gs.washington.edu.ORCID 0000-0002-8246-4014
Funding
Sequence and Assembly of Segmental DuplicationsR01HG002385 · NHGRI · UNIVERSITY OF WASHINGTON · PI Evan Eichler · 2001 to 2026
$13.3MInstrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9MImproving the Human Reference Genome ResourceU41HG007635 · NHGRI · WASHINGTON UNIVERSITY · PI WILSON, RICHARD K. · 2014 to 2017
$9.6MGenetic Variation in Age-Related Macular DegenerationR01EY013435 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALLIKMETS, RANDO L · 2001 to 2014
$7.7MHoward Hughes Medical InstituteNEI NIH HHS P30 EY019007NEI NIH HHS R01 EY013435NHGRI NIH HHS R01 HG002385NHGRI NIH HHS U41 HG007635
Abstract
Structural variation and single-nucleotide variation of the complement factor H (
Indexed as
Evolution, MolecularMutationPolymorphism, Single NucleotideSelection, GeneticAnimalsComplement Factor HExonsGenetic Predisposition to DiseaseGenotypeHaplotypesHumansMacular DegenerationMultigene FamilyPhenotypePrimatesRisk FactorsCFH protein, humanComplement Factor Hage-related macular degenerationAMDCFH gene familynatural selectionstructural variation
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.